UNLABELLED: Big data-based artificial intelligence (AI) has become increasingly important in medicine and may be helpful in the future to predict diseases and outcomes. For severely injured patients, a new analytics tool has recently been developed (WATSON Trauma Pathway Explorer) to assess individual risk profiles early after trauma. We performed a validation of this tool and a comparison with the Trauma and Injury Severity Score (TRISS), an established trauma survival estimation score. Prospective data collection, level I trauma centre, 1 January 2018-31 December 2019. INCLUSION CRITERIA: Primary admission for trauma, injury severity score (ISS) ≥ 16, age ≥ 16. PARAMETERS: Age, ISS, temperature, presence of head injury by the Glasgow Coma Scale (GCS). OUTCOMES: SIRS and sepsis within 21 days and early death within 72 h after hospitalisation. STATISTICS: Area under the receiver operating characteristic (ROC) curve for predictive quality, calibration plots for graphical goodness of fit, Brier score for overall performance of WATSON and TRISS. Between 2018 and 2019, 107 patients were included (33 female, 74 male; mean age 48.3 ± 19.7; mean temperature 35.9 ± 1.3; median ISS 30, IQR 23-36). The area under the curve (AUC) is 0.77 (95% CI 0.68-0.85) for SIRS and 0.71 (95% CI 0.58-0.83) for sepsis. WATSON and TRISS showed similar AUCs to predict early death (AUC 0.90, 95% CI 0.79-0.99 vs. AUC 0.88, 95% CI 0.77-0.97; = 0.75). The goodness of fit of WATSON ( = 8.19, Hosmer-Lemeshow = 0.42) was superior to that of TRISS ( = 31.93, Hosmer-Lemeshow < 0.05), as was the overall performance based on Brier score (0.06 vs. 0.11 points). The validation supports previous reports in terms of feasibility of the WATSON Trauma Pathway Explorer and emphasises its relevance to predict SIRS, sepsis, and early death when compared with the TRISS method.