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（唇形科）普鲁斯基（菊科）甲醇提取物通过抑制BCR/ABL诱导白血病细胞凋亡。

(L.) Pruski (Asteraceae) Methanol Extract Induces Apoptosis in Leukemia Cells through Suppression of BCR/ABL.

作者信息

Chi Hoang Thanh, Thuong Nguyen Thi Lien, Ly Bui Thi Kim

机构信息

Faculty of Food Technology, Institute of Applied Technology, Thu Dau Mot University, Thu Dau Mot City 820000, Binh Duong Province, Vietnam.

出版信息

Plants (Basel). 2021 May 14;10(5):980. doi: 10.3390/plants10050980.

DOI:10.3390/plants10050980
PMID:34068907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8156756/
Abstract

We will study the effects of the methanol extract of (L.) Pruski (Asteraceae) (MeST) on the growth of leukemia cells that may contain the gene. This study also clarifies the mechanism of this effect on these cells. For this purpose, the cells harboring wild-type BCR/ABL, imatinib-resistant BCR/ABL (K562 and TCCYT315I), or Ba/F3 cells transfected with wild-type or mutant genes were used. The results showed that MeST effectively inhibited the viability of leukemia cells in both a dose- and time-dependent manner. The effect of MeST seems to be more sensitive in the cells that carry imatinib-resistant BCR/ABL (especially the T315I BCR/ABL mutation) than those with wild-type BCR/ABL. Furthermore, we have demonstrated that the death caused by MeST is apoptosis and the treatment with MeST could suppress the expression of BCR/ABL, subsequently altering the downstream cascade of BCR/ABL such as AKT and MAPK signaling. In conclusion, MeST has been able to suppress the growth of leukemia cells harboring BCR/ABL. The mechanism of the anti-leukemic effect of MeST on cells harboring imatinib-resistant BCR/ABL mutations could be due to the disruption of the BCR/ABL oncoprotein signaling cascade.

摘要

我们将研究毛果一枝香（菊科）甲醇提取物（MeST）对可能含有该基因的白血病细胞生长的影响。本研究还阐明了这种对这些细胞影响的机制。为此，使用了携带野生型BCR/ABL、伊马替尼耐药的BCR/ABL（K562和TCCYT315I）的细胞，或转染了野生型或突变基因的Ba/F3细胞。结果表明，MeST以剂量和时间依赖性方式有效抑制白血病细胞的活力。MeST对携带伊马替尼耐药BCR/ABL（尤其是T315I BCR/ABL突变）的细胞的作用似乎比携带野生型BCR/ABL的细胞更敏感。此外，我们已经证明MeST导致的细胞死亡是凋亡，并且用MeST处理可以抑制BCR/ABL的表达，随后改变BCR/ABL的下游级联反应，如AKT和MAPK信号传导。总之，MeST能够抑制携带BCR/ABL的白血病细胞的生长。MeST对携带伊马替尼耐药BCR/ABL突变的细胞的抗白血病作用机制可能是由于BCR/ABL癌蛋白信号级联的破坏。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f3/8156756/ce82cda30f44/plants-10-00980-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f3/8156756/c7f9a7c90bf0/plants-10-00980-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f3/8156756/643cee1e9345/plants-10-00980-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f3/8156756/165c357f7964/plants-10-00980-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f3/8156756/92bdc241efa6/plants-10-00980-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f3/8156756/c038799759d3/plants-10-00980-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f3/8156756/3410dc934503/plants-10-00980-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f3/8156756/ce82cda30f44/plants-10-00980-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f3/8156756/c7f9a7c90bf0/plants-10-00980-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f3/8156756/643cee1e9345/plants-10-00980-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f3/8156756/165c357f7964/plants-10-00980-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f3/8156756/92bdc241efa6/plants-10-00980-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f3/8156756/c038799759d3/plants-10-00980-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f3/8156756/3410dc934503/plants-10-00980-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11f3/8156756/ce82cda30f44/plants-10-00980-g007.jpg

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