Yan Zhaokun, Lai Zijun, Lin Jiumao
Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122. China.
Academy of Integrative Medicine, Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, P.O. Box: 350122, 1 Qiuyang Road, Minhou Shangjie, Fuzhou, Fujian. China.
Comb Chem High Throughput Screen. 2017;20(5):423-429. doi: 10.2174/1386207320666170116141818.
Cancer is a systemic disease. Cancer occurrence is associated with several factors, including cell proliferation, apoptosis, metastasis, tumor microenvironment and immune system. Traditional Chinese medicine (TCM) has been widely used for thousands of years in China for its anti-cancer therapeutic effect. The advantage of using TCM is related to its action on multiple signaling pathways and molecular targets related to cancer, whilst causing few adverse effects.
The review focuses on the most recent studies on TCM through examples that demonstrate the anticancer effects and the mechanisms.
The review shows a large number of works which demonstrated that TCM is useful in the treatment of various types of cancers through different mechanisms of action. The results indicate that TCM exerts its anticancer effects through apoptosis induction, proliferation inhibition, metastasis suppression, multidrug resistance reversal and immune function regulation. Moreover, TCM can improve patients' quality of life. The advantage of TCM suggests that TCM may represent a promising therapeutic approach for patients with diverse cancers.
癌症是一种全身性疾病。癌症的发生与多种因素相关，包括细胞增殖、凋亡、转移、肿瘤微环境和免疫系统。中药在中国已被广泛使用数千年，因其具有抗癌治疗作用。使用中药的优势与其对与癌症相关的多种信号通路和分子靶点的作用有关，同时副作用较少。
本综述通过实例聚焦于中药的最新研究，这些实例展示了其抗癌作用及机制。
本综述展示了大量研究成果，这些研究表明中药通过不同的作用机制对治疗各种类型的癌症有效。结果表明，中药通过诱导凋亡、抑制增殖、抑制转移、逆转多药耐药和调节免疫功能发挥抗癌作用。此外，中药可以提高患者的生活质量。中药的优势表明其可能是治疗多种癌症患者的一种有前景的治疗方法。
