Pascolini R, Lorvik S, Maci R, Camatini M
Istituto di Anatomia Comparata, Università di Perugia.
Tissue Cell. 1988;20(2):157-63. doi: 10.1016/0040-8166(88)90038-9.
Wound repair in planarians is mainly characterized by two cell-migratory events involving the epidermis adjacent to the wound and its basement membrane. The first event is the migration of epidermal cells to cover the wound surface; the second one is the migration of newly differentiating replacement epidermal cells from the parenchyma to the epidermis. In addition to these events, migration of fixed parenchymal cells is observed during wound healing. All migrating cells were characterized by the presence of actin, as shown by the results obtained by means of indirect immunolocalization with fluorescent and electron microscopy. Migrating cells were heavily labeled with gold particles, which clustered at the level of cell-matrix and cell-cell contacts.
涡虫的伤口修复主要特征是两个涉及伤口附近表皮及其基底膜的细胞迁移事件。第一个事件是表皮细胞迁移以覆盖伤口表面；第二个事件是新分化的替代表皮细胞从实质组织迁移到表皮。除了这些事件外，在伤口愈合过程中还观察到固定实质细胞的迁移。如通过荧光和电子显微镜间接免疫定位获得的结果所示，所有迁移细胞的特征是存在肌动蛋白。迁移细胞被大量金颗粒标记，这些金颗粒聚集在细胞 - 基质和细胞 - 细胞接触的水平。
