Rudge M F, Duncan C J
University of Liverpool, Department of Zoology.
Tissue Cell. 1988;20(2):249-53. doi: 10.1016/0040-8166(88)90046-8.
Changes in the ultrastructure of the cardiac muscle cells have been followed in dystrophic mice and hamsters (22-40 weeks of age) and in both species a severe cardiomyopathy accompanies the cellular damage of the skeletal muscle. The degradative changes of the myofilament apparatus of the heart cells and the specific changes in mitochondrial ultrastructure (including swelling, septation and apparent division) are characteristic of the cellular damage of both the dystrophic skeletal muscle and of normal cardiac muscle in which [Ca]i has been experimentally raised, confirming the suggestions that (i) the same gene is responsible for the myopathy of skeletal and cardiac muscle in animal dystrophy and (ii) that changes in [Ca]i are implicated in the degradative changes of muscle cells.
在营养不良的小鼠和仓鼠（22至40周龄）中，已对心肌细胞的超微结构变化进行了跟踪研究。在这两个物种中，严重的心肌病都伴随着骨骼肌的细胞损伤。心脏细胞肌丝装置的降解变化以及线粒体超微结构的特定变化（包括肿胀、分隔和明显分裂）是营养不良性骨骼肌和实验性提高[Ca]i的正常心肌细胞损伤的特征，这证实了以下观点：（i）同一基因负责动物营养不良中骨骼肌和心肌的肌病；（ii）[Ca]i的变化与肌肉细胞的降解变化有关。
