Percy D H, Thakar J H, Strickland K P
Muscle Nerve. 1979 Jul-Aug;2(4):288-94. doi: 10.1002/mus.880020408.
Cardiomyopathic hamsters (UM-X7.1 strain) have demonstrable myopathy involving both skeletal and cardiac muscle. In addition, they have multiple ocular abnormalities. In this study, extraocular muscles were examined by light and electron microscopy. Changes observed within affected muscle fibers were variable and included coagulation necrosis, lysis of myofibrils, mitochondrial changes, and infiltration by phagocytic cells. Regenerative changes included duplication of myoblast nuclei, proliferation of sarcoplasmic reticulum, and myofibrillogenesis. The lesions are presumably myogenic in origin. The cardiomyopathic hamster may be useful as an animal model for certain types of ocular myopathy in man.
患有心肌病的仓鼠（UM-X7.1 品系）表现出明显的涉及骨骼肌和心肌的肌病。此外，它们还有多种眼部异常。在本研究中，通过光学显微镜和电子显微镜对眼外肌进行了检查。在受影响的肌纤维内观察到的变化各不相同，包括凝固性坏死、肌原纤维溶解、线粒体变化以及吞噬细胞浸润。再生变化包括成肌细胞核的复制、肌浆网的增殖和肌原纤维生成。这些病变推测起源于肌源性。患有心肌病的仓鼠可能作为人类某些类型眼肌病的动物模型。
