Kim Jihyun, Lee Hoyoung, Choi Tae-Young, Kim Joong Il, Kang Byoung-Kab, Lee Myeong Soo, Joo Jong Kil, Lee Kyu Sup, You Sooseong
Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Korea.
Department of Obstetrics and Gynecology, Pusan National University, Busan 49241, Korea.
J Clin Med. 2021 May 18;10(10):2182. doi: 10.3390/jcm10102182.
Acupuncture is believed to improve ovarian reserve and reproductive outcomes in women undergoing in vitro fertilization (IVF). This study was conducted to evaluate the effect of network-optimized acupuncture followed by IVF on the oocyte yield in women showing a poor ovarian response. This study was an exploratory randomized controlled trial conducted from June 2017 to January 2020 at the Pusan National University Hospital. Women diagnosed with poor ovarian response were enrolled and randomly divided into two groups: IVF alone and Ac + IVF groups (16 acupuncture sessions before IVF treatment). Eight acupoints with high degree centrality and betweenness centrality were selected using network analysis. Among the participants, compared with the IVF treatment alone, the acupuncture + IVF treatment significantly increased the number of retrieved mature oocytes in women aged more than 37 years and in those undergoing more than one controlled ovarian hyperstimulation cycle. The negative correlation between the number of retrieved mature oocytes and consecutive controlled ovarian hyperstimulation cycles was not observed in the Ac + IVF group irrespective of the maternal age. These findings suggest that physicians can consider acupuncture for the treatment of women with poor ovarian response and aged > 37 years or undergoing multiple IVF cycles.
针刺疗法被认为可以改善接受体外受精（IVF）的女性的卵巢储备和生殖结局。本研究旨在评估网络优化针刺疗法联合IVF对卵巢反应不良女性的卵母细胞产量的影响。本研究是一项探索性随机对照试验，于2017年6月至2020年1月在釜山国立大学医院进行。招募被诊断为卵巢反应不良的女性，并随机分为两组：单纯IVF组和针刺+IVF组（IVF治疗前进行16次针刺治疗）。使用网络分析选择了8个具有高度中心性和中介中心性的穴位。在参与者中，与单纯IVF治疗相比，针刺+IVF治疗显著增加了37岁以上女性以及接受过一个以上控制性卵巢刺激周期的女性中回收的成熟卵母细胞数量。无论产妇年龄如何，针刺+IVF组均未观察到回收的成熟卵母细胞数量与连续控制性卵巢刺激周期之间的负相关。这些发现表明，医生可以考虑对卵巢反应不良、年龄>37岁或接受多个IVF周期的女性进行针刺治疗。
