Martín-Sanz Raquel, Sayagués José María, García-Cano Pilar, Azcue-Mayorga Mikel, Parra-Pérez María Del Carmen, Pacios-Pacios María Ángeles, Piqué-Durán Enric, Feito Jorge
Ophthalmology Department, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, Spain.
Pathology Department, Complejo Asistencial Universitario de Salamanca, 37007 Salamanca, Spain.
Dermatopathology (Basel). 2021 May 25;8(2):147-158. doi: 10.3390/dermatopathology8020021.
Proliferating trichilemmal tumours (PTT) are defined by a benign squamous cell proliferation inside a trichilemmal cystic (TC) cavity. A possible explanation of this proliferative phenomenon within the cyst may be molecular alterations in genes associated to cell proliferation, which can be induced by ultraviolet radiation. Among other genes, alterations on and DNA mismatch repair proteins (MMR) may be involved in the cellular proliferation observed in PTT. Based on this assumption, but also taking into account the close relationship between the sebaceous ducts and the external root sheath where TC develop, a MMR, a p53 expression assessment and a study were performed in a series of 5 PTT cases, including a giant one. We failed to demonstrate a MMR disorder on studied PTT, but we agree with previous results suggesting increased p53 expression in these tumours, particularly in proliferative areas. alteration was confirmed with FISH technique, demonstrating deletion in most cells.
增殖性外毛根鞘瘤（PTT）由外毛根鞘囊肿（TC）腔内的良性鳞状细胞增殖所定义。囊肿内这种增殖现象的一种可能解释是与细胞增殖相关基因的分子改变，这可能由紫外线辐射诱导。在其他基因中， 和DNA错配修复蛋白（MMR）的改变可能参与了PTT中观察到的细胞增殖。基于这一假设，同时考虑到皮脂腺导管与TC发生部位的外根鞘之间的密切关系，对一系列5例PTT病例（包括1例巨大型）进行了MMR、p53表达评估和一项 研究。我们未能在研究的PTT中证明MMR紊乱，但我们同意先前的结果，即这些肿瘤中p53表达增加，特别是在增殖区域。通过荧光原位杂交（FISH）技术证实了 改变，显示大多数细胞中 缺失。
