Naciri Ilhame, Hassam Baderddine
Service de Dermatologie et Vénérologie, Centre Hospitalier Universitaire IBN SINA, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.
Pan Afr Med J. 2017 Sep 18;28:45. doi: 10.11604/pamj.2017.28.45.13535. eCollection 2017.
Proliferating trichilemmal tumor (PTT), still referred to as proliferative trichilemmal cyst (TC), is an uncommon malignant adnexal tumor originating from the cells of the outer root sheath of the hair follicle or, more often, from a trichilemmal cyst, following multiple trauma and/or recurrent inflammation. We report the case of a 64-year old female patient, with no particular previous history, presenting with tumor of the scalp gradually evolving over 18 months. Clinical examination showed a painless, firm, adhering ulcero-budding tumor mass measuring 12 cm along its longer axis at the level of the vertex. The patient had clinically negative lymph nodes. Histological examination showed malpighian cell proliferation arranged in clumps and coalescing lobules with focal areas of abrupt trichilemmal keratinization, with very marked atypies cyto-nuclear and an infiltrated fibrous stroma, suggesting proliferating trichilemmal tumor. Staging evaluation showed no metastase. The patient underwent wide surgical resection followed by in depth removal of extra tissue, without recurrence at 3-months' follow-up.
增生性毛鞘瘤（PTT），仍被称为增生性毛鞘囊肿（TC），是一种罕见的恶性附属器肿瘤，起源于毛囊外根鞘细胞，或更常见的是在多次创伤和/或反复炎症后起源于毛鞘囊肿。我们报告一例64岁女性患者，既往无特殊病史，头皮肿物逐渐发展18个月。临床检查显示在头顶水平有一个无痛、质地硬、附着的溃疡样隆起肿瘤，长轴12厘米。患者临床检查淋巴结阴性。组织学检查显示马尔皮基细胞呈团块状和融合性小叶状增生，有局灶性突然的毛鞘角化区域，细胞核异型性非常明显，纤维间质浸润，提示为增生性毛鞘瘤。分期评估未发现转移。患者接受了广泛的手术切除，随后深入切除额外组织，随访3个月无复发。
