Bermúdez Ana, Arranz-Salas Isabel, Mercado Silvia, López-Villodres Juan A, González Virginia, Ríus Francisca, Ortega María V, Alba Carmen, Hierro Isabel, Bermúdez Diego
Department of Anesthesiology, Nuestra Señora de Valme University Hospital, 41014 Seville, Spain.
Department of Human Physiology, Human Histology, Anatomical Pathology and Physical Education, University of Malaga, 29010 Malaga, Spain.
Diagnostics (Basel). 2021 May 25;11(6):944. doi: 10.3390/diagnostics11060944.
Gastric cancer (GC) is one of the leading causes of cancer-related death. The combination of new molecular classifications with clinicopathological data could contribute to the individualization of patients and to the development of new therapeutic strategies. We examined the various associations in two molecular types of GC: HER2-positive (human epidermal growth factor receptor 2) and microsatellite instability (MSI), assessing their influence on treatment and prognosis. A retrospective study of 142 GC patients was performed with molecular characterization through HER2 overexpression and DNA repair protein expression for MSI. The percentage of HER2-positive tumors was 13.4%, predominantly in men. Correlations were found with intestinal type, metastases, advanced stages and chemotherapy. Almost 75% of HER2-positive patients died. MSI occurred in 16.2%, associated with advanced age, female sex, distal location and intestinal type. These patients had few metastases and low stages. The percentage of deaths was higher among MSI patients who received perioperative chemotherapy. The determination of HER2 and MSI status in GC is important for their association with specific clinicopathological features and for their prognostic and predictive value.
胃癌（GC）是癌症相关死亡的主要原因之一。新的分子分类与临床病理数据相结合有助于患者的个体化治疗以及新治疗策略的开发。我们研究了两种分子类型的胃癌中的各种关联：HER2阳性（人表皮生长因子受体2）和微卫星不稳定性（MSI），评估它们对治疗和预后的影响。对142例胃癌患者进行了回顾性研究，通过HER2过表达和DNA修复蛋白表达对MSI进行分子特征分析。HER2阳性肿瘤的比例为13.4%，主要见于男性。发现其与肠型、转移、晚期和化疗相关。几乎75%的HER2阳性患者死亡。MSI发生率为16.2%，与高龄、女性、远端部位和肠型相关。这些患者转移较少且分期较低。接受围手术期化疗的MSI患者死亡率较高。确定胃癌中的HER2和MSI状态对于它们与特定临床病理特征的关联以及它们的预后和预测价值很重要。
