Slocombe R F, Slauson D O
Department of Pathology, College of Veterinary Medicine, Michigan State University, East Lansing.
Vet Pathol. 1988 Jul;25(4):277-81. doi: 10.1177/030098588802500405.
Invasive pulmonary aspergillosis was identified in 19 horses. In 16 cases mycotic lesions were associated with enterocolitis; 14 cases appeared to result from Salmonella infection. Pulmonary lesions included multifocal areas of acute necrosis, leukocytoclastic vasculitis, and thrombosis with fibrinosuppurative inflammation surrounding mycelial masses. Thromboemboli with fungi were in the brain and kidneys of three cases. Factors which appeared to predispose to pulmonary aspergillosis included corticosteroid therapy, disseminated neoplasms, hepatitis, pleuritis, and peritonitis. This study suggests that immunocompromise and invasion of Aspergillus sp. from damaged intestine are more important in causing equine pulmonary aspergillosis than inhalation of spores.
19匹马被确诊患有侵袭性肺曲霉病。16例真菌性病变与小肠结肠炎相关；14例似乎由沙门氏菌感染所致。肺部病变包括多灶性急性坏死区域、白细胞破碎性血管炎以及血栓形成，并伴有围绕菌丝团块的纤维蛋白化脓性炎症。3例病例的脑和肾中出现了伴有真菌的血栓栓塞。易患肺曲霉病的因素包括皮质类固醇治疗、播散性肿瘤、肝炎、胸膜炎和腹膜炎。这项研究表明，免疫功能低下以及曲霉属真菌从受损肠道的侵袭在导致马属动物肺曲霉病方面比吸入孢子更为重要。
