新冠病毒相关嗅觉功能障碍中的神经感觉康复与嗅觉网络恢复
Neurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory Dysfunction.
作者信息
Chung Tom Wai-Hin, Zhang Hui, Wong Fergus Kai-Chuen, Sridhar Siddharth, Chan Kwok-Hung, Cheng Vincent Chi-Chung, Yuen Kwok-Yung, Hung Ivan Fan-Ngai, Mak Henry Ka-Fung
机构信息
Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Department of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
出版信息
Brain Sci. 2021 May 23;11(6):686. doi: 10.3390/brainsci11060686.
Abstract
Non-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and olfactory network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One patient received olfactory treatment (OT) by the combination of oral vitamin A and smell training via the novel electronic portable aromatic rehabilitation (EPAR) diffusers. After four-weeks of OT, clinical recuperation of smell was correlated with interval increase of bilateral OB volumes [right: 22.5 mm to 49.5 mm (120%), left: 37.5 mm to 42 mm (12%)] and improvement of mean olfactory FC [0.09 to 0.15 (66.6%)].
摘要
非传导性嗅觉功能障碍（OD）是2019冠状病毒病（COVID-19）的一种重要肺外表现。在两名患有长期COVID-19相关OD的患者中，发现了嗅球（OB）体积减小和嗅觉网络功能连接（FC）缺陷。一名患者通过口服维生素A和使用新型电子便携式芳香康复（EPAR）扩散器进行嗅觉训练（OT）相结合的方式接受治疗。经过四周的OT，嗅觉的临床恢复与双侧OB体积的间隔增加[右侧：22.5 mm至49.5 mm（120%），左侧：37.5 mm至42 mm（12%）]以及平均嗅觉FC的改善[0.09至0.15（66.6%）]相关。
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