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Frailty Assessment in a Cohort of Elderly Patients with Severe Symptomatic Aortic Stenosis: Insights from the FRailty Evaluation in Severe Aortic Stenosis (FRESAS) Registry.一组有严重症状的老年主动脉瓣狭窄患者的衰弱评估：来自严重主动脉瓣狭窄衰弱评估（FRESAS）注册研究的见解
J Clin Med. 2021 May 27;10(11):2345. doi: 10.3390/jcm10112345.
2
Restricted mean survival time of older adults with severe aortic stenosis referred for transcatheter aortic valve replacement.老年严重主动脉瓣狭窄患者行经导管主动脉瓣置换术的限制平均生存时间。
BMC Cardiovasc Disord. 2020 Jun 18;20(1):299. doi: 10.1186/s12872-020-01572-4.
3
1-Year Clinical Outcomes in Women After Transcatheter Aortic Valve Replacement: Results From the First WIN-TAVI Registry.经导管主动脉瓣置换术后女性 1 年的临床结局：来自首个 WIN-TAVI 注册研究的结果。
JACC Cardiovasc Interv. 2018 Jan 8;11(1):1-12. doi: 10.1016/j.jcin.2017.09.034.
4
Frailty and Bleeding in Older Adults Undergoing TAVR or SAVR: Insights From the FRAILTY-AVR Study.老年 TAVR 或 SAVR 患者的衰弱和出血：来自 FRAILTY-AVR 研究的见解。
JACC Cardiovasc Interv. 2020 May 11;13(9):1058-1068. doi: 10.1016/j.jcin.2020.01.238.
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Frailty in Older Adults Undergoing Aortic Valve Replacement: The FRAILTY-AVR Study.老年主动脉瓣置换术患者的衰弱：FRAILTY-AVR 研究。
J Am Coll Cardiol. 2017 Aug 8;70(6):689-700. doi: 10.1016/j.jacc.2017.06.024. Epub 2017 Jul 7.
6
The impact of frailty status on clinical and functional outcomes after transcatheter aortic valve replacement in nonagenarians with severe aortic stenosis.衰弱状态对患有严重主动脉瓣狭窄的非agenarians经导管主动脉瓣置换术后临床和功能结局的影响。 注：这里“nonagenarians”翻译为“九旬老人”更合适，整句译文：衰弱状态对患有严重主动脉瓣狭窄的九旬老人经导管主动脉瓣置换术后临床和功能结局的影响。
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A Practical Two-Stage Frailty Assessment for Older Adults Undergoing Aortic Valve Replacement.用于主动脉瓣置换术老年患者的实用两阶段衰弱评估。
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Factors influencing the choice between transcatheter and surgical treatment of severe aortic stenosis in patients younger than 80 years: Results from the OBSERVANT study.影响 80 岁以下严重主动脉瓣狭窄患者经导管与手术治疗选择的因素：来自 OBSERVANT 研究的结果。
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The Erasmus Frailty Score is associated with delirium and 1-year mortality after Transcatheter Aortic Valve Implantation in older patients. The TAVI Care & Cure program.在接受经导管主动脉瓣植入术的老年患者中，爱拉斯谟虚弱评分与谵妄和 1 年死亡率相关。TAVI Care & Cure 项目。
Int J Cardiol. 2019 Feb 1;276:48-52. doi: 10.1016/j.ijcard.2018.10.093. Epub 2018 Oct 28.
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Habitual Physical Activity in Older Adults Undergoing TAVR: Insights From the FRAILTY-AVR Study.老年经导管主动脉瓣置换术患者的习惯性体力活动：来自 FRAILTY-AVR 研究的见解。
JACC Cardiovasc Interv. 2019 Apr 22;12(8):781-789. doi: 10.1016/j.jcin.2019.02.049.

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J Clin Med. 2025 Jan 8;14(2):334. doi: 10.3390/jcm14020334.
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Prognostic impact of muscle ultrasound-guided diagnosis of sarcopenia in older adults with severe aortic stenosis.肌肉超声引导下诊断肌肉减少症对重度主动脉瓣狭窄老年患者的预后影响
Eur Geriatr Med. 2024 Dec;15(6):1645-1656. doi: 10.1007/s41999-024-01042-6. Epub 2024 Sep 4.
3
[Cognitive impairment in the elderly patient with symptomatic severe aortic stenosis. Therapeutic decisions and impact on one-year mortality].[有症状的重度主动脉瓣狭窄老年患者的认知障碍。治疗决策及其对一年死亡率的影响]
Rev Neurol. 2023 Feb 16;76(4):127-135. doi: 10.33588/rn.7604.2022300.
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The role of stress echocardiography in transcatheter aortic valve implantation and transcatheter edge-to-edge repair era: A systematic review.负荷超声心动图在经导管主动脉瓣植入术和经导管缘对缘修复时代的作用：一项系统评价。
Front Cardiovasc Med. 2022 Nov 16;9:964669. doi: 10.3389/fcvm.2022.964669. eCollection 2022.

本文引用的文献

1
Atrial fibrillation and frailty.心房颤动与衰弱
J Geriatr Cardiol. 2020 Feb;17(2):105-109. doi: 10.11909/j.issn.1671-5411.2020.02.007.
2
Frailty: implications for clinical practice and public health.虚弱：对临床实践和公共卫生的影响。
Lancet. 2019 Oct 12;394(10206):1365-1375. doi: 10.1016/S0140-6736(19)31786-6.
3
Habitual Physical Activity in Older Adults Undergoing TAVR: Insights From the FRAILTY-AVR Study.老年经导管主动脉瓣置换术患者的习惯性体力活动：来自 FRAILTY-AVR 研究的见解。
JACC Cardiovasc Interv. 2019 Apr 22;12(8):781-789. doi: 10.1016/j.jcin.2019.02.049.
4
A New Functional Classification Based on Frailty and Disability Stratifies the Risk for Mortality Among Older Adults: The FRADEA Study.基于虚弱和残疾的新功能分类可对老年人的死亡率风险进行分层：FRADEA 研究。
J Am Med Dir Assoc. 2019 Sep;20(9):1105-1110. doi: 10.1016/j.jamda.2019.01.129. Epub 2019 Mar 8.
5
Factors Associated with Discharge to a Skilled Nursing Facility after Transcatheter Aortic Valve Replacement Surgery.经导管主动脉瓣置换术后转至熟练护理机构的相关因素。
Int J Environ Res Public Health. 2018 Dec 28;16(1):73. doi: 10.3390/ijerph16010073.
6
The Erasmus Frailty Score is associated with delirium and 1-year mortality after Transcatheter Aortic Valve Implantation in older patients. The TAVI Care & Cure program.在接受经导管主动脉瓣植入术的老年患者中，爱拉斯谟虚弱评分与谵妄和 1 年死亡率相关。TAVI Care & Cure 项目。
Int J Cardiol. 2019 Feb 1;276:48-52. doi: 10.1016/j.ijcard.2018.10.093. Epub 2018 Oct 28.
7
A novel geriatric assessment frailty score predicts 2-year mortality after transcatheter aortic valve implantation.一种新的老年综合评估衰弱评分可预测经导管主动脉瓣置换术后 2 年的死亡率。
Eur Heart J Qual Care Clin Outcomes. 2019 Apr 1;5(2):153-160. doi: 10.1093/ehjqcco/qcy044.
8
Contemporary review of severe aortic stenosis.当代主动脉瓣重度狭窄的研究进展
Intern Med J. 2019 Mar;49(3):297-305. doi: 10.1111/imj.14071.
9
Comprehensive geriatric assessment in patients undergoing transcatheter aortic valve implantation - results from the CGA-TAVI multicentre registry.经导管主动脉瓣植入术患者的综合老年评估——CGA-TAVI多中心注册研究结果
BMC Cardiovasc Disord. 2018 Jan 4;18(1):1. doi: 10.1186/s12872-017-0740-x.
10
Impact of Frailty on Outcomes in Patients Undergoing Percutaneous Mitral Valve Repair.衰弱对行经皮二尖瓣修复术患者结局的影响。
JACC Cardiovasc Interv. 2017 Oct 9;10(19):1920-1929. doi: 10.1016/j.jcin.2017.07.042.

一组有严重症状的老年主动脉瓣狭窄患者的衰弱评估：来自严重主动脉瓣狭窄衰弱评估（FRESAS）注册研究的见解

Frailty Assessment in a Cohort of Elderly Patients with Severe Symptomatic Aortic Stenosis: Insights from the FRailty Evaluation in Severe Aortic Stenosis (FRESAS) Registry.

作者信息

Solla-Suárez Pablo, Avanzas Pablo, Pascual Isaac, Bermúdez-Menéndez De La Granda Manuel, Almendarez Marcel, Arche-Coto Jose M, Hernández-Vaquero Daniel, Lorca Rebeca, López-Álvarez Eva, Álvarez-Velasco Rut, Moreno-Planillo Carmen, Morís de la Tassa César, Gutiérrez-Rodríguez José

机构信息

Área de Gestión Clínica de Geriatría, Hospital Monte Naranco, 33011 Oviedo, Spain.

Instituto de Investigación Sanitaria del Principado de Asturias, 33011 Oviedo, Spain.

出版信息

J Clin Med. 2021 May 27;10(11):2345. doi: 10.3390/jcm10112345.

DOI:10.3390/jcm10112345
PMID:34071871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8197816/
Abstract

BACKGROUND

Precise evaluation of the degree of frailty is a fundamental part of the global geriatric assessment that helps to avoid therapies that could be futile. Our main objective was to determine the prevalence of frailty in a specific consult of patients undergoing aortic valve replacement.

METHODS

From May 2018 to February 2020, all consecutive patients ≥75 years old, with severe symptomatic aortic stenosis, undergoing valve replacement in the Principality of Asturias (Northern Spain) were evaluated.

RESULTS

A total of 286 patients were assessed. The mean age was 84 ± 4.01 years old; 175 (61.2%) were female. The short performance physical battery score was 8.5 ± 2.4 and the prevalence of frailty was 19.6% (56 patients). In the multivariable analysis, age, Barthel index and atrial fibrillation were independent predictors of frailty.

CONCLUSIONS

The prevalence of frailty in our sample patients undergoing aortic valve replacement, evaluated by a standardized protocol, was 19.6%.

摘要

背景

准确评估衰弱程度是全球老年医学评估的基本组成部分，有助于避免无效治疗。我们的主要目标是确定接受主动脉瓣置换术的特定患者群体中衰弱的患病率。

方法

2018年5月至2020年2月，对西班牙北部阿斯图里亚斯公国所有连续的、年龄≥75岁、患有严重症状性主动脉瓣狭窄且正在接受瓣膜置换术的患者进行评估。

结果

共评估了286例患者。平均年龄为84±4.01岁；175例（61.2%）为女性。简易体能状况量表评分为8.5±2.4，衰弱患病率为19.6%（56例患者）。在多变量分析中，年龄、巴氏指数和心房颤动是衰弱的独立预测因素。

结论

通过标准化方案评估，我们样本中接受主动脉瓣置换术的患者衰弱患病率为19.6%。