Psillas George, Dimas Grigorios G, Sarafidou Anastasia, Didangelos Triantafyllos, Perifanis Vasilios, Kaiafa Georgia, Mirkopoulou Daphne, Tegos Thomas, Savopoulos Christos, Constantinidis Jiannis
1st Academic ENT Department, Aristotle University of Thessaloniki, AHEPA Hospital, 1, Stilponos Kyriakidi St., 546 36 Thessaloniki, Greece.
1st Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 1, Stilponos Kyriakidi St., 546 36 Thessaloniki, Greece.
J Clin Med. 2021 May 27;10(11):2357. doi: 10.3390/jcm10112357.
The aim of this study is to evaluate the effects of diabetes mellitus, hypertension and hypercholesterolemia on the clinical presentation and outcome of Bell's palsy. The study (comorbidity) group consisted of 50 patients with Bell's palsy associated with diabetes, hypertension, or hypercholesterolemia; the control group included 46 patients with Bell's palsy, but without comorbid diseases. The House-Brackmann grading system (I to VI) was used in order to assess the initial and final facial functions. Both groups of patients were treated with steroids and the antiviral agent acyclovir. The mean severity of initial facial paralysis was more significant in diabetes, hypercholesterolemia, and hypertension, in comparison to the control group. Patients suffering from Bell's palsy and concomitant comorbidities have a poorer prognosis (HB III-VI) compared to patients without comorbidities. Increased glycosylated hemoglobin A1c levels (>6.7%) were significantly correlated with unsatisfactory facial recovery. The pathogenetic mechanisms by which diabetes, hypercholesterolemia, and hypertension affect the vasa nervosum of facial nerve have been described.
本研究的目的是评估糖尿病、高血压和高胆固醇血症对贝尔面瘫临床表现及预后的影响。研究（合并症）组由50例患有贝尔面瘫且合并糖尿病、高血压或高胆固醇血症的患者组成；对照组包括46例患有贝尔面瘫但无合并症的患者。采用House - Brackmann分级系统（I至VI级）来评估初始和最终的面部功能。两组患者均接受类固醇和抗病毒药物阿昔洛韦治疗。与对照组相比，糖尿病、高胆固醇血症和高血压患者初始面瘫的平均严重程度更高。与无合并症的患者相比，患有贝尔面瘫及合并症的患者预后较差（HB III - VI级）。糖化血红蛋白A1c水平升高（>6.7%）与面部恢复不理想显著相关。已经描述了糖尿病、高胆固醇血症和高血压影响面神经血管的发病机制。
