Bińczak Jakub, Dziuba Krzysztof, Chrobok Anna
Department of Chemical Organic Technology and Petrochemistry, PhD School, Silesian University of Technology, Akademicka 2a, 44-100 Gliwice, Poland.
Grupa Azoty Zakłady Azotowe, Puławy" S.A., Al. Tysiąclecia Państwa Polskiego 13, 24-110 Puławy, Poland.
Materials (Basel). 2021 May 27;14(11):2881. doi: 10.3390/ma14112881.
Lactones are a group of compounds that have been known for several decades. The commercial importance of lactones results from the possibility of manufacturing of a broad scope of derivatives and polymers with a wide spectrum of applications. In this work the synthesis and characterization of simple lactones are described, which due to the easy methods of the synthesis are of high importance for the industry. The chemical as well as biochemical methods are included with special attention paid to the methods that avoid metal catalysts, initiators or toxic solvents, allowing the use of the final products for the medical applications, e.g., for controlled drug-release systems, resorbable surgical threads, implants, tissue scaffolds or for the production of drugs. Lactone-based derivatives, such as polymers, copolymers, composites or three-dimensional structures are also presented. The work is focused on the methods for the synthesis of lactones and lactones derivates, as well as on the special properties and application of the studied compounds.
内酯是一类已被人们知晓数十年的化合物。内酯的商业重要性源于制造具有广泛应用的多种衍生物和聚合物的可能性。在这项工作中，描述了简单内酯的合成与表征，由于其合成方法简便，对工业具有高度重要性。其中包括化学方法以及生物化学方法，特别关注那些避免使用金属催化剂、引发剂或有毒溶剂的方法，从而使得最终产品能够用于医疗应用，例如用于控释药物系统、可吸收手术缝线、植入物、组织支架或用于药物生产。还介绍了基于内酯的衍生物，如聚合物、共聚物、复合材料或三维结构。这项工作聚焦于内酯及其衍生物的合成方法，以及所研究化合物的特殊性质和应用。
