Department of Food Science and Technology, Oregon State University, Corvallis, OR 97331, USA.
Seafood Research and Education Center, Oregon State University, Astoria, OR 97103, USA.
Molecules. 2021 May 27;26(11):3225. doi: 10.3390/molecules26113225.
The interest in utilizing food-derived compounds therapeutically has been rising. With the growing prevalence of systematic chronic inflammation (SCI), efforts to find treatments that do not result in the side effects of current anti-inflammatory drugs are underway. Bioactive peptides (BAPs) are a particularly promising class of compounds for the treatment of SCI, and the abundance of high-quality seafood processing byproducts (SPB) makes it a favorable material to derive anti-inflammatory BAPs. Recent research into the structural properties of anti-inflammatory BAPs has found a few key tendencies including they tend to be short and of low molecular weight (LMW), have an overall positive charge, contain hydrophobic amino acids (AAs), and be rich in radical scavenging AAs. SPB-derived anti-inflammatory BAPs have been observed to work via inhibition of the NF-κB and MAPK pathways by disrupting the phosphorylation of IκBα and one or more kinases (ERK, JNK, and p38), respectively. Radical scavenging capacity has also been shown to play a significant role in the efficacy of SPB-derived anti-inflammatory BAPs. To determine if SPB-derived BAPs can serve as an effective treatment for SCI it will be important to understand their properties and mechanisms of action, and this review highlights such findings in recent research.
人们对利用食物衍生化合物进行治疗的兴趣日益浓厚。随着系统性慢性炎症 (SCI) 的患病率不断上升，人们正在努力寻找不会产生当前抗炎药物副作用的治疗方法。生物活性肽 (BAPs) 是治疗 SCI 的一类特别有前途的化合物，高质量海鲜加工副产物 (SPB) 的丰富性使其成为衍生抗炎 BAPs 的理想材料。最近对抗炎 BAPs 结构特性的研究发现了一些关键趋势，包括它们往往短且分子量低 (LMW)，带正电荷，含有疏水性氨基酸 (AAs)，富含自由基清除氨基酸 (AAs)。观察到 SPB 衍生的抗炎 BAPs 通过分别破坏 IκBα 和一种或多种激酶 (ERK、JNK 和 p38) 的磷酸化来抑制 NF-κB 和 MAPK 途径起作用。自由基清除能力也被证明在 SPB 衍生抗炎 BAPs 的功效中发挥了重要作用。为了确定 SPB 衍生的 BAPs 是否可以作为治疗 SCI 的有效方法，了解它们的特性和作用机制非常重要，本综述重点介绍了最近研究中的这些发现。
