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[局部应用糖皮质激素对外毛根鞘增殖行为影响的DNA脉冲细胞光度学研究]

[DNA impulse cytophotometric studies of the modification of the proliferation behavior of the outer hair root sheath by topical glucocorticoid administration].

作者信息

Schell H, Kiesewetter F, Pausch C, Arai A

机构信息

Dermatologische Universitäts-Klinik Erlangen.

出版信息

Z Hautkr. 1988 Jun 15;63(6):505-8.

PMID:3407265
Abstract

A corticoid preparation (C) was topically applied on the scalps of 47 healthy test persons for 7 or 14 days, resp. After this treatment, we plucked anagen hairs under standardized conditions both from the area treated with C and the contralateral, untreated area. The proliferative activity of plucked anagen hairs with root sheaths was analyzed by means of DNA flow cytometry. Already a 7 days treatment with topical C resulted in kinetic changes of the outer root sheath: The percentage of the cells in the G1/10-phase of the cell cycle was increased, whereas that of the cells in the S-phase and the G2+M-phase was decreased.

摘要

将一种皮质激素类制剂（C）分别在47名健康受试者的头皮上局部应用7天或14天。治疗后，我们在标准化条件下从用C治疗的区域和对侧未治疗区域拔取生长期毛发。通过DNA流式细胞术分析带有毛根鞘的拔取的生长期毛发的增殖活性。局部应用C仅7天的治疗就导致了外根鞘的动力学变化：细胞周期中G1/10期的细胞百分比增加，而S期和G2+M期的细胞百分比降低。

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