Mulet Bayona Juan Vicente, Tormo Palop Nuria, Salvador García Carme, Fuster Escrivá Begoña, Chanzá Aviñó Mercedes, Ortega García Pilar, Gimeno Cardona Concepción
Department of Microbiology and Parasitology, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, Spain.
Department of Hospital Pharmacy, Consorcio Hospital General Universitario de Valencia, 46014 Valencia, Spain.
J Fungi (Basel). 2021 May 31;7(6):440. doi: 10.3390/jof7060440.
In addition to the increase in fungal infections that has been observed in the last few decades, it has been reported that severe clinical COVID-19 can increase the risk of invasive fungal infections. The main objective of this study was to evaluate if there had been an increase in candidaemia and invasive pulmonary aspergillosis (IPA) cases since the onset of the SARS-CoV-2 pandemic. Data were retrospectively collected from April 2019 to March 2021, from patients admitted to Consorcio Hospital General Universitario de Valencia (Spain). A total of 152 candidaemia cases (56 of which were due to ) and 108 possible IPA cases were detected. A great increase in candidaemia cases was produced during the first and the third epidemic waves of the SARS-CoV-2 pandemic (June 2020, and January 2021, respectively), while an increase in IPA cases was produced during the third wave. The 28-day mortality rates in patients affected by candidaemia and IPA increased in 2020 and 2021. has displaced the other species, becoming the most isolated species in blood cultures since the onset of the SARS-CoV-2 pandemic. Antifungal consumption increased in 2020 when compared to 2019, especially echinocandins, voriconazole and isavuconazole.
除了在过去几十年中观察到的真菌感染增加外，据报道，严重的COVID-19临床病例会增加侵袭性真菌感染的风险。本研究的主要目的是评估自SARS-CoV-2大流行开始以来，念珠菌血症和侵袭性肺曲霉病（IPA）病例是否有所增加。数据回顾性收集于2019年4月至2021年3月，来自西班牙巴伦西亚综合大学医院收治的患者。共检测到152例念珠菌血症病例（其中56例病因不明）和108例可能的IPA病例。在SARS-CoV-2大流行的第一波和第三波疫情期间（分别为2020年6月和2021年1月），念珠菌血症病例大幅增加，而IPA病例在第三波疫情期间增加。2020年和2021年，受念珠菌血症和IPA影响的患者的28天死亡率有所上升。[某种念珠菌名称]已取代其他[念珠菌名称]物种，自SARS-CoV-2大流行开始以来，成为血培养中分离最多的[念珠菌名称]物种。与2019年相比，2020年抗真菌药物的消耗量有所增加，尤其是棘白菌素、伏立康唑和艾沙康唑。
