Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Lampung, Bandar Lampung 35145, Indonesia.
Indonesia National Agency of Food and Drug Control, Bandar Lampung 35228, Indonesia.
Molecules. 2021 May 24;26(11):3130. doi: 10.3390/molecules26113130.
This research aimed at developing an analysis method, which was optimized and validated to determine the content of mercury in skin lightening cream discovered in the market in Bandar Lampung, Indonesia, through the use of microwave plasma atomic emission spectroscopy (MP-AES). The optimization on the analysis method was conducted on pump rate, viewing position, and reductant concentration in order to obtain the highest mercury emission intensity, while the solution stability was optimized to know the stability of mercury in the solution. The result showed that the method developed had precision with a relative standard deviation of 2.67%, recovery value of 92.78%, and linearity with an r value of 0.993, respectively. The sensitivity of the instrument detection had a limit of analysis method detection and quantification of 0.59 and 1.98 µg/L, respectively. The results of the test of the lightening cream (8 of 16 samples) positively contained mercury in the range of 422.61-44,960.79 ng/g. Therefore the method of analysis developed may be used for routine analysis of chemicals in any cosmetics products.
本研究旨在开发一种分析方法,该方法通过使用微波等离子体原子发射光谱(MP-AES)对在印度尼西亚班达楠榜市市场上发现的美白霜中的汞含量进行优化和验证。通过优化分析方法的泵速、观察位置和还原剂浓度,以获得最高的汞发射强度,同时优化溶液稳定性以了解溶液中汞的稳定性。结果表明,所开发的方法具有精密度,相对标准偏差为 2.67%,回收率为 92.78%,线性度为 0.993,分别。仪器检测的灵敏度具有分析方法检测限和定量限,分别为 0.59 和 1.98 µg/L。对美白霜(16 个样本中的 8 个)的测试结果显示,汞含量在 422.61-44,960.79ng/g 范围内呈阳性。因此,所开发的分析方法可用于任何化妆品产品中化学物质的常规分析。