Department of Ophthalmology, The Second Hospital of Jilin University, Changchun 130000, China.
Biomolecules. 2021 May 24;11(6):789. doi: 10.3390/biom11060789.
Organ fibrosis is a common pathological result of various chronic diseases with multiple causes. Fibrosis is characterized by the excessive deposition of extracellular matrix and eventually leads to the destruction of the tissue structure and impaired organ function. Prostaglandins are produced by arachidonic acid through cyclooxygenases and various prostaglandin-specific synthases. Prostaglandins bind to homologous receptors on adjacent tissue cells in an autocrine or paracrine manner and participate in the regulation of a series of physiological or pathological processes, including fibrosis. This review summarizes the properties, synthesis, and degradation of various prostaglandins, as well as the roles of these prostaglandins and their receptors in fibrosis in multiple models to reveal the clinical significance of prostaglandins and their receptors in the treatment of fibrosis.
器官纤维化是多种慢性疾病的常见病理结果，其病因众多。纤维化的特征是细胞外基质的过度沉积，最终导致组织结构破坏和器官功能受损。前列腺素是由花生四烯酸通过环氧化酶和各种前列腺素特异性合成酶产生的。前列腺素以自分泌或旁分泌的方式与相邻组织细胞上的同源受体结合，并参与一系列生理或病理过程的调节，包括纤维化。本综述总结了各种前列腺素的特性、合成和降解，以及这些前列腺素及其受体在多种模型中在纤维化中的作用，以揭示前列腺素及其受体在纤维化治疗中的临床意义。
