Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, PR China.
Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, PR China.
Talanta. 2021 Sep 1;232:122445. doi: 10.1016/j.talanta.2021.122445. Epub 2021 Apr 30.
As the highest form of molecular recognition, the chiral molecular recognition is the most difficult measurements. Herein, a disposable dual-signal enantioselective platform was fabricated based on stereoscopic porous chiral carbon nanotubes hydrogel modified screen printed electrode. This kind of chiral hydrogel was prepared by a simple heating method with l-cysteine and chiral single-walled carbon nanotubes of chirality (6,5), and its dispersion and morphology were characterized by several techniques including scanning electron microscopy, Fourier transform infrared spectroscopy, Raman spectroscopy, X-ray photoelectron spectroscopy and electrochemical impedance spectroscopy. The stereogenic chiral interface was successfully employed to discriminate mandelic acid enantiomers via both oxidation peak intensity and peak potential value of cyclic voltammetry. The chiral recognition mechanism was discussed specifically, which resulted from the formation of an efficient three-dimensional chiral nanospace. The inherent chirality of chiral carbon nanotubes hydrogel, together with their orderly spatial arrangement, can significantly improve the efficiency of chiral recognition compared with traditional electrochemical chiral sensors. As a novel chiral sensing interface, such chiral carbon nanotubes hydrogel was simple to prepare, fast to operate, with good sensitivity and excellent stability for the construction of efficient and practical electrochemical chiral sensors.
作为最高形式的分子识别，手性分子识别是最困难的测量。在此，基于立体多孔手性碳纳米管水凝胶修饰的丝网印刷电极，制备了一种一次性双信号对映选择性平台。这种手性水凝胶是通过简单的加热方法用 l-半胱氨酸和手性单壁碳纳米管（6,5）制备的，其分散体和形态通过几种技术进行了表征，包括扫描电子显微镜、傅里叶变换红外光谱、拉曼光谱、X 射线光电子能谱和电化学阻抗谱。立体手性界面成功地通过循环伏安法的氧化峰强度和峰电位值来区分扁桃酸对映体。具体讨论了手性识别机制，这是由于形成了有效的三维手性纳米空间。手性碳纳米管水凝胶的固有手性及其有序的空间排列与传统的电化学手性传感器相比，可以显著提高手性识别的效率。作为一种新型的手性传感界面，这种手性碳纳米管水凝胶制备简单，操作快速，具有良好的灵敏度和优异的稳定性，可用于构建高效实用的电化学手性传感器。
