Cancer Research Center of Lyon, UMR INSERM 1052, CNRS 5286, Université Claude Bernard Lyon 1, Labex DEVweCAN, Centre Léon Bérard, Lyon, France.
Cancer Research Center of Lyon, UMR INSERM 1052, CNRS 5286, Université Claude Bernard Lyon 1, Labex DEVweCAN, Centre Léon Bérard, Lyon, France.
Int Rev Cell Mol Biol. 2021;361:245-300. doi: 10.1016/bs.ircmb.2020.10.006. Epub 2020 Nov 1.
T cells (or T lymphocytes) exhibit a myriad of functions in immune responses, ranging from pathogen clearance to autoimmunity, cancer and even non-lymphoid tissue homeostasis. Therefore, deciphering the molecular mechanisms orchestrating their specification, function and gene expression pattern is critical not only for our comprehension of fundamental biology, but also for the discovery of novel therapeutic targets. Among the master regulators of T-cell identity, the functions of the NF-κB family of transcription factors have been under scrutiny for several decades. However, a more precise understanding of their pleiotropic functions is only just emerging. In this review we will provide a global overview of the roles of NF-κB in the different flavors of mature T cells. We aim at highlighting the complex and sometimes diverging roles of the five NF-κB subunits in health and disease.
T 细胞（或 T 淋巴细胞）在免疫反应中表现出多种功能，从病原体清除到自身免疫、癌症，甚至非淋巴组织的稳态。因此，解析协调它们的特异性、功能和基因表达模式的分子机制不仅对我们理解基础生物学至关重要，而且对发现新的治疗靶点也至关重要。在 T 细胞特性的主要调控因子中，NF-κB 转录因子家族的功能已经受到了几十年的关注。然而，人们对它们的多功能性的理解才刚刚开始。在这篇综述中，我们将全面概述 NF-κB 在不同成熟 T 细胞中的作用。我们旨在强调五个 NF-κB 亚基在健康和疾病中的复杂且有时不同的作用。
