Section of Paediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, USA.
Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO, USA.
Diabetologia. 2021 Aug;64(8):1709-1716. doi: 10.1007/s00125-021-05480-w. Epub 2021 Jun 1.
Globally, the proportion of new diagnoses of youth-onset diabetes represented by type 2 diabetes is increasing, and youth with type 2 diabetes commonly have complications and comorbidities, as well as a higher rate of mortality. In this review, we summarise what is known about the natural progression of youth-onset type 2 diabetes from published clinical trials and large-scale prospective epidemiological studies. It is important to note that the robust pathophysiological and treatment data specifically related to individuals with a diabetes onset at ≤20 years of age largely hails from the USA. Youth-onset type 2 diabetes is characterised by pathophysiological heterogeneity and inadequate glycaemic control, highlighting the need for new treatment approaches and innovative study designs in populations of varied genetic and cultural backgrounds.
从已发表的临床试验和大型前瞻性流行病学研究来看，在全球范围内，青年发病的 2 型糖尿病新诊断病例中，2 型糖尿病的比例正在增加，而且青年 2 型糖尿病患者通常存在并发症和合并症，以及更高的死亡率。在这篇综述中，我们总结了已知的关于青年发病 2 型糖尿病的自然病程。需要注意的是，与发病年龄≤20 岁的个体相关的稳健的病理生理学和治疗数据主要来自美国。青年发病 2 型糖尿病的特点是病理生理学异质性和血糖控制不佳，这凸显了在具有不同遗传和文化背景的人群中需要新的治疗方法和创新的研究设计。
