自身免疫性疾病患者复发性静脉血栓栓塞的风险：来自血栓栓塞登记处（RIETE）登记的资料。
Risk of recurrent venous thromboembolism in patients with autoimmune diseases: data from the Registro Informatizado de Enfermedad TromboEmbólica (RIETE) registry.
机构信息
Department of Hematology, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands.
Department of Internal Medicine, Hospital Reina Sofía, Tudela, Navarra, Spain.
出版信息
Br J Haematol. 2021 Jul;194(1):195-199. doi: 10.1111/bjh.17549. Epub 2021 Jun 2.
Abstract
Autoimmune disease is a risk factor for first incident venous thromboembolism (VTE). However, data on the risk of recurrent VTE in people with autoimmune disease is sparse. We explored the risk of recurrent VTE using the RIETE registry, comparing people with autoimmune disease (n = 1305) to those without (n = 50608). Overall rates were 6.5 and 5.1 recurrent VTE/100 years for patients with autoimmune disease vs controls, respectively. After adjustment for sex and unprovoked/provoked VTE yielded an adjusted hazard ratio of 1.29 (95%CI 1.03-1.62). The analysis was limited by short median follow up time (161 days overall), precluding definitive conclusions on recurrent VTE risks.
摘要
自身免疫性疾病是首发静脉血栓栓塞症（VTE）的一个风险因素。然而，关于自身免疫性疾病患者复发性 VTE 的风险数据很少。我们使用 RIETE 登记处研究了复发性 VTE 的风险，将自身免疫性疾病患者（n=1305）与无自身免疫性疾病患者（n=50608）进行了比较。自身免疫性疾病患者和对照组的总体复发 VTE 率分别为 6.5 和 5.1/100 人年。调整性别和未诱发/诱发 VTE 后，调整后的风险比为 1.29（95%CI 1.03-1.62）。分析受到总体中位随访时间（161 天）较短的限制，无法确定复发性 VTE 风险的明确结论。
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