Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Int J Dermatol. 2021 Nov;60(11):e433-e439. doi: 10.1111/ijd.15671. Epub 2021 Jun 1.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that presents with recurrent inflammatory nodules and draining tunnels in the skin. Most HS studies have focused on Western populations, and the understanding of how HS characteristics differ in specific Asian ethnicities is poor. We conducted the first systematic review and meta-analysis to characterize HS patients from East and Southeast Asia. PubMed, Embase, and Ovid MEDLINE databases were searched from inception to June 12, 2020. English-language case-series, cross-sectional, observational, and randomized controlled trial studies investigating HS in East and Southeast Asian populations were screened by titles, abstracts, and articles in duplicate. Of 136 citations, 10 studies were included in the meta-analysis. Data on gender distribution, lesion distribution in the axilla and gluteal regions, and family history were extracted in duplicate. A random effects model was used for the meta-analysis. A total of 30,125 HS patients were included in the analysis. Most patients were male (66%, 95% CI = 60-72%). About half of Asian patients with HS develop lesions in the axilla (52%, 95% CI = 33-72%) and the buttocks (48%, 95% CI = 38-57%). Only a small subset had positive family history of HS (5%, 95% CI = 2-8%). We report an up-to-date characterization of HS in East and Southeast Asian populations and highlight differences in their Western counterparts. These results will hopefully improve understanding for how HS may manifest, lead to more personalized treatments for Asian patients with HS, and usher in a proper patient-centered approach to treating the disease.
化脓性汗腺炎（HS）是一种慢性炎症性皮肤病，表现为皮肤反复出现炎症性结节和引流窦道。大多数 HS 研究都集中在西方人群，而对特定亚洲种族 HS 特征的差异了解甚少。我们进行了首次系统评价和荟萃分析，以描述东亚和东南亚的 HS 患者。从创建到 2020 年 6 月 12 日，我们在 PubMed、Embase 和 Ovid MEDLINE 数据库中进行了检索。通过标题、摘要和文章对研究东亚和东南亚人群 HS 的英文病例系列、横断面、观察性和随机对照试验进行了双重筛选。在 136 条引文中有 10 项研究被纳入荟萃分析。对性别分布、腋窝和臀部病变分布以及家族史的数据进行了重复提取。荟萃分析采用随机效应模型。共纳入 30125 例 HS 患者。大多数患者为男性（66%，95%CI=60-72%）。约一半的亚洲 HS 患者在腋窝（52%，95%CI=33-72%）和臀部（48%，95%CI=38-57%）出现病变。仅有一小部分患者有 HS 的阳性家族史（5%，95%CI=2-8%）。我们报告了东亚和东南亚人群 HS 的最新特征，并强调了其与西方人群的差异。这些结果有望提高对 HS 可能表现的认识，为亚洲 HS 患者提供更个性化的治疗，并为治疗该疾病引入适当的以患者为中心的方法。
