Böttcher Benjamin, Lorbeer Roberto, Stöcklein Sophia, Beller Ebba, Lang Cajetan I, Weber Marc-André, Meinel Felix G
Institute of Diagnostic and Interventional Radiology, Paediatric Radiology and Neuroradiology, University Medical Centre Rostock, Rostock, Germany.
Department of Radiology, Ludwig-Maximilian University, Munich, Germany.
J Magn Reson Imaging. 2021 Dec;54(6):1763-1772. doi: 10.1002/jmri.27755. Epub 2021 Jun 1.
Mapping of T1 and T2 relaxation times in cardiac MRI is an invaluable tool for the diagnosis and risk stratification of a wide spectrum of cardiac diseases.
To investigate the global and regional reproducibility of native T1 and T2 mapping and to analyze the influence of demographic factors, physiological parameters, slice position, and myocardial regions on reproducibility.
Prospective single-center cohort-study.
Fifty healthy volunteers (29 female, 21 male) with a mean age of 39.4 ± 13.7 years.
FIELD STRENGTH/SEQUENCE: Each volunteer was investigated twice at 1.5 T using a modified look-locker inversion-recovery (MOLLI) sequence (T1 mapping) and a T2-prepared steady-state free precession (SSFP) sequence (T2 mapping).
Global T1 and T2 values were quantified for the entire left ventricle in three short-axis slices. Regional T1 and T2 values were measured for each myocardial segment and for myocardial segments grouped by slice position and anatomical region.
Test-retest reproducibility was assessed using intraclass correlation coefficient (ICC) and Bland-Altman statistics. A P value < 0.05 was considered statistically significant.
Reproducibility was good for global T1 values (ICC 0.88) and excellent for global T2 values (ICC 0.91). Reproducibility of T1 values was excellent (ICC 0.91) for midventricular slice and good for apical (ICC 0.86) and basal slice (ICC 0.81). Reproducibility of T1 mapping values was highest in the septum (ICC 0.90) compared to the anterior (0.81), lateral (0.86), and inferior (0.86) wall. For T2 mapping, reproducibility was good for all slice positions (ICC 0.86 for midventricular, 0.83 for basal, and 0.80 for apical slice). Reproducibility of T2 mapping was significantly lower for the inferior wall (ICC 0.58) than for septum (0.89), anterior (0.85), and lateral (0.87) wall.
Native T1 and T2 mapping has good to excellent reproducibility with significant regional differences.
2 TECHNICAL EFFICACY: Stage 2.
心脏磁共振成像（MRI）中T1和T2弛豫时间的映射是诊断和对多种心脏疾病进行风险分层的重要工具。
研究天然T1和T2映射的整体和区域可重复性，并分析人口统计学因素、生理参数、切片位置和心肌区域对可重复性的影响。
前瞻性单中心队列研究。
50名健康志愿者（29名女性，21名男性），平均年龄39.4±13.7岁。
场强/序列：每位志愿者在1.5T场强下使用改良的锁相环反转恢复（MOLLI）序列（T1映射）和T2准备稳态自由进动（SSFP）序列（T2映射）进行两次检查。
在三个短轴切片中对整个左心室的整体T1和T2值进行量化。对每个心肌节段以及按切片位置和解剖区域分组的心肌节段测量区域T1和T2值。
使用组内相关系数（ICC）和Bland-Altman统计量评估重测可重复性。P值<0.05被认为具有统计学意义。
整体T1值的可重复性良好（ICC 0.88），整体T2值的可重复性极佳（ICC 0.91）。心室中部切片的T1值可重复性极佳（ICC 0.91），心尖部（ICC 0.86）和基部切片（ICC 0.81）的可重复性良好。与前壁（0.81）、侧壁（0.86）和下壁（0.86）相比，T1映射值在室间隔的可重复性最高（ICC 0.90）。对于T2映射，所有切片位置的可重复性都良好（心室中部ICC 0.86，基部ICC 0.83，心尖部切片ICC 0.80）。下壁的T2映射可重复性（ICC 0.58）明显低于室间隔（0.89）、前壁（0.85）和侧壁（0.87）。
天然T1和T2映射具有良好至极佳的可重复性，且存在显著的区域差异。
2 技术效能：2级。
