Meyer J H, Doty J E
Department of Medicine, Sepulveda VA Hospital, CA.
Am J Clin Nutr. 1988 Aug;48(2):267-73. doi: 10.1093/ajcn/48.2.267.
These experiments were undertaken in dogs with midintestinal fistulas to determine whether guar added to a meal of solid food would disrupt gastric sieving and give rise to maldigestion of solid food. Dogs were fed a standard meal of steak, chicken liver, bread, margarine, and water in which there was 0, 3.3, 7.5, or 15 g guar powder. The margarine or the liver contained [14C]triolein. Using an isotope ratio method, we determined how much [14C]triolein was absorbed at midintestine. We found that guar in a dose-related fashion increased the weight of chyme collected at midintestine, markedly reduced the percent of triolein absorbed by midintestine from 88 to 38%, and profoundly increased the passage to midintestine of large, poorly digestible pieces of steak and liver. The viscosity of the guar promoted the GI transit of large, poorly digestible pieces of food but also reduced absorption by other mechanisms.
这些实验是在患有中肠瘘的狗身上进行的，目的是确定在固体食物餐中添加瓜尔胶是否会扰乱胃筛分并导致固体食物消化不良。给狗喂食标准餐，包括牛排、鸡肝、面包、人造黄油和水，其中瓜尔胶粉末的含量分别为0、3.3、7.5或15克。人造黄油或肝脏中含有[14C]三油酸甘油酯。使用同位素比率法，我们测定了在中肠吸收的[14C]三油酸甘油酯的量。我们发现，瓜尔胶以剂量相关的方式增加了在中肠收集的食糜重量，显著降低了中肠吸收的三油酸甘油酯百分比，从88%降至38%，并极大地增加了牛排和肝脏等大的、难消化的碎片向中肠的通过。瓜尔胶的粘性促进了大的、难消化的食物碎片在胃肠道中的转运，但也通过其他机制降低了吸收。
