Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.
J Am Chem Soc. 2021 Jun 16;143(23):8597-8602. doi: 10.1021/jacs.1c03718. Epub 2021 Jun 2.
A method for C-H bond amination via an electrophotocatalytic Ritter-type reaction is described. The reaction is catalyzed by a trisaminocyclopropenium (TAC) ion in an electrochemical cell under irradiation. These conditions convert benzylic C-H bonds to acetamides without the use of a stoichiometric chemical oxidant. A range of functionality is shown to be compatible with this transformation, and several complex substrates are demonstrated.
描述了一种通过光电催化里特型反应进行 C-H 键胺化的方法。该反应在电化学电池中在光照下由三氨基环丙烯鎓(TAC)离子催化。在这些条件下,反应无需使用化学计量氧化剂即可将苄基 C-H 键转化为乙酰胺。该转化方法兼容多种官能团,并且可以对多种复杂底物进行转化。