Programa de Pós-graduação em Ciências Biológicas: Bioquímica, ICBS, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Nutr Neurosci. 2022 Oct;25(10):2066-2076. doi: 10.1080/1028415X.2021.1933330. Epub 2021 Jun 2.
Polyphenols are compounds found in plants that have been extensively studied due to the health benefits of its consumption in adulthood. Meanwhile, recent evidence suggests that polyphenol consumption during pregnancy may not be safe for the fetus.
The goal of this study was to evaluate the effect of naringenin supplementation during pregnancy on brain redox homeostasis and mitochondrial activity of the newborn rat.
Adult female Wistar rats were divided into two groups: (1) vehicle (1 mL/Kg p.o.) or (2) naringenin (50 mg/Kg p.o.). Naringenin was administered once a day during pregnancy. The offspring were euthanized on postnatal day 7, as well the dams, and brain regions were dissected.
The offspring cerebellum was the most affected region, presenting increased activity of the mitochondrial electron transport system, allied to increased reactive species levels, lipid peroxidation, and glutathione concentration. The nitric oxide levels suffered structure-dependent alteration, with decreased levels in the pups' cerebellum and increased in the hippocampus. The offspring parietal cortex was not affected, as well as the parameters evaluated in the dams' brains.
Maternal consumption of naringenin alters offspring cerebellar redox homeostasis, which could be related to adverse effects on the motor and cognitive development in the descendants.
多酚是植物中含有的化合物，由于其在成年期摄入对健康有益，因此已被广泛研究。与此同时，最近的证据表明，怀孕期间多酚的摄入可能对胎儿不安全。
本研究旨在评估怀孕期间补充柚皮素对新生大鼠大脑氧化还原平衡和线粒体活性的影响。
成年雌性 Wistar 大鼠分为两组：（1）载体（1mL/kg，口服）或（2）柚皮素（50mg/kg，口服）。柚皮素在怀孕期间每天给药一次。幼仔于产后第 7 天处死，同时处死母鼠，并分离大脑区域。
幼仔小脑是受影响最严重的区域，表现出线粒体电子传递系统活性增加，同时活性物质水平、脂质过氧化和谷胱甘肽浓度增加。一氧化氮水平发生了结构依赖性改变，小脑中的水平降低，而海马中的水平升高。幼仔顶叶皮层未受影响，母鼠大脑中评估的参数也未受影响。
母体摄入柚皮素改变了后代小脑的氧化还原平衡，这可能与后代运动和认知发育的不良影响有关。
