Biomedical Engineering, University of Wisconsin, Madison, USA.
Mechanical Engineering, University of Wisconsin, Madison, USA.
Biomech Model Mechanobiol. 2021 Oct;20(5):1659-1674. doi: 10.1007/s10237-021-01468-y. Epub 2021 Jun 2.
A distributed lumped parameter (DLP) model of blood flow was recently developed that can be simulated in minutes while still incorporating complex sources of energy dissipation in blood vessels. The aim of this work was to extend the previous DLP modeling framework to include fluid-structure interactions (DLP-FSI). This was done by using a simple compliance term to calculate pressure that does not increase the simulation complexity of the original DLP models. Verification and validation studies found DLP-FSI simulations had good agreement compared to analytical solutions of the wave equations, experimental measurements of pulsatile flow in elastic tubes, and in vivo MRI measurements of thoracic aortic flow. This new development of DLP-FSI allows for significantly improved computational efficiency of FSI simulations compared to FSI approaches that solve the full 3D conservation of mass and momentum equations while also including the complex sources of energy dissipation occurring in cardiovascular flows that other simplified models neglect.
最近开发了一种分布式集中参数 (DLP) 血流模型，该模型可以在几分钟内进行模拟，同时仍能纳入血管中复杂的能量耗散源。本工作的目的是将先前的 DLP 建模框架扩展到包括流固相互作用 (DLP-FSI)。这是通过使用简单的顺应性项来计算压力来实现的，而不会增加原始 DLP 模型的模拟复杂性。验证和验证研究发现，与波动方程的解析解、弹性管中脉动流的实验测量以及胸主动脉流的体内 MRI 测量相比，DLP-FSI 模拟具有很好的一致性。与求解完整的 3D 质量和动量守恒方程并纳入心血管流动中其他简化模型忽略的复杂能量耗散源的 FSI 方法相比，DLP-FSI 的这一新发展允许显著提高 FSI 模拟的计算效率。
