Mechanical Engineering, University of California, Berkeley, CA, 94720, USA.
Mechanical Engineering, University of California, Berkeley, CA, 94720, USA.
J Biomech. 2022 Jul;140:111161. doi: 10.1016/j.jbiomech.2022.111161. Epub 2022 Jun 2.
We extend our previous distributed lumped parameter (DLP) modeling approach to take into account blood vessel wall deformability. This is achieved by adding a compliance term for each vascular segment based on 1D NS equations. The results of the proposed method are compared against 1D Navier-Stokes and 3D fluid-structure interaction (FSI) modeling in idealized and patient-specific models. We show that 1D Navier-Stokes blood flow modeling can be highly inaccurate in predicting flow and pressure dynamics in diseased cases, while in comparison the DLP approach produces consistently accurate flow and pressure waveforms as compared to 3D FSI modeling. The relative accuracy and computational efficiency of the proposed DLP approach offer the possibility to replace or augment 1D or 3D modeling to study hemodynamics in a variety of applications.
我们扩展了之前的分布式集中参数 (DLP) 建模方法，以考虑血管壁的可变形性。这是通过根据 1D NS 方程为每个血管段添加一个顺应性项来实现的。所提出方法的结果与理想模型和患者特定模型中的 1D 纳维-斯托克斯方程和 3D 流固耦合 (FSI) 建模进行了比较。我们表明，1D 纳维-斯托克斯血流模型在预测病变情况下的血流和压力动态时可能非常不准确，而相比之下，DLP 方法产生的血流和压力波形与 3D FSI 建模相比始终准确。所提出的 DLP 方法的相对准确性和计算效率提供了用各种应用研究血液动力学来替代或补充 1D 或 3D 建模的可能性。
