Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, 727 South Jingming Rd., Kunming, Yunnan, China.
PET/CT Center, First People's Hospital of Yunnan, 157 Jinbi Rd., Kunming, Yunnan, China.
Jpn J Radiol. 2021 Nov;39(11):1086-1096. doi: 10.1007/s11604-021-01140-6. Epub 2021 Jun 2.
PET enables a concurrent evaluation of perfusion status and metabolic activity. We aimed to evaluate the feasibility of perfusion and early-uptake F-FDG PET/CT in hepatocellular carcinoma (HCC) using a dual-input dual-compartment uptake model.
Data from 5 min dynamic PET/CT and conventional PET/CT scans were retrospectively collected from 17 pathologically diagnosed HCCs. Parameters such as hepatic arterial blood flow (Fa), portal vein blood flow (Fv), total blood flow (F), hepatic arterial perfusion index (HPI), portal vein perfusion index (PPI), blood volume (BV), extracellular mean transit time (MTT) and intracellular uptake rate (Ki) were calculated. Fa, HPI, MTT and Ki images were generated and used to identify HCC.
Compared with the surrounding liver tissue, HCCs showed significant increases in Fa, HPI, Ki and the maximum standard uptake value (SUVmax) (all P < 0.001) and significant reductions in Fv (P < 0.05) and PPI (P < 0.001). F, BV and MTT (all P > 0.05) did not differ significantly between HCCs and the surrounding liver tissue. Perfusion and early-uptake PET/CT increased the positivity rate of HCCs from 52.9% with conventional PET/CT alone to 88.2% with the combined method (P < 0.05).
Perfusion and early-uptake PET/CT are feasible for diagnosing HCC and provide added functional information to enhance diagnostic performance.
PET 能够同时评估灌注状态和代谢活性。我们旨在使用双输入双室摄取模型评估灌注和早期摄取 F-FDG PET/CT 在肝细胞癌（HCC）中的可行性。
回顾性收集了 17 例经病理诊断为 HCC 的患者的 5 分钟动态 PET/CT 和常规 PET/CT 扫描数据。计算了肝动脉血流量（Fa）、门静脉血流量（Fv）、总血流量（F）、肝动脉灌注指数（HPI）、门静脉灌注指数（PPI）、血容量（BV）、细胞外平均传输时间（MTT）和细胞内摄取率（Ki）等参数。生成了 Fa、HPI、MTT 和 Ki 图像，并用于识别 HCC。
与周围肝组织相比，HCC 表现出 Fa、HPI、Ki 和最大标准摄取值（SUVmax）的显著增加（均 P<0.001），Fv（P<0.05）和 PPI（P<0.001）的显著降低。HCC 与周围肝组织之间的 F、BV 和 MTT（均 P>0.05）没有显著差异。灌注和早期摄取 PET/CT 将 HCC 的阳性率从单独使用常规 PET/CT 的 52.9%提高到联合方法的 88.2%（P<0.05）。
灌注和早期摄取 PET/CT 可用于诊断 HCC，并提供额外的功能信息以提高诊断性能。
