Torkashvand Hossein, Shabani Ronak, Amiri Iraj, Darakhshan Roya, Maleki Behnam, Doostabadi Mohammad Reza, Mehdizadeh Mehdi
Department of Anatomical Science, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran.
Avicenna J Med Biotechnol. 2024 Jul-Sep;16(3):156-164. doi: 10.18502/ajmb.v16i3.15741.
This review addresses the current understanding of Maturation (IVM) treatment, including indications and effective treatment protocols influencing oocyte developmental competence. A comprehensive literature search was performed to gather relevant studies, clinical trials, and reviews related to IVM. Databases such as PubMed, MEDLINE, and pertinent medical journals were searched. The selected literature was analyzed and synthesized to offer a comprehensive overview. IVM has emerged as a promising technique for inducing maturation in immature oocytes across various developmental stages. Its applications extend to areas utilizing In Vitro Fertilization (IVF), gaining traction as a treatment option for Polycystic Ovary Syndrome (PCOS) and fertility preservation in cancer patients. Recent advancements have led to improved global pregnancy rates, resulting in successful births. IVM also holds potential in reducing risks associated with conventional IVF, including ovarian hyperstimulation syndrome and multiple pregnancies. Despite these advantages, IVM adoption in clinical practice remains limited. Ongoing research aims to refine therapeutic protocols and expand clinical indications. IVM holds promise in assisted reproductive technology, spanning applications from cancer patient fertility preservation to addressing PCOS. Enhanced pregnancy rates highlight efficacy, while risk reduction compared to IVF underscores its importance. Further research is needed for optimal use across patient groups, emphasizing protocol refinement and expanded applications.
本综述阐述了对未成熟卵母细胞体外成熟（IVM）治疗的当前认识，包括影响卵母细胞发育能力的适应症和有效治疗方案。进行了全面的文献检索，以收集与IVM相关的研究、临床试验和综述。检索了PubMed、MEDLINE等数据库以及相关医学期刊。对所选文献进行分析和综合，以提供全面概述。IVM已成为一种有前景的技术，可诱导不同发育阶段的未成熟卵母细胞成熟。其应用扩展到利用体外受精（IVF）的领域，作为多囊卵巢综合征（PCOS）的治疗选择和癌症患者生育力保存方法越来越受到关注。最近的进展提高了总体妊娠率，实现了成功分娩。IVM在降低与传统IVF相关的风险方面也具有潜力，包括卵巢过度刺激综合征和多胎妊娠。尽管有这些优势，但IVM在临床实践中的应用仍然有限。正在进行的研究旨在完善治疗方案并扩大临床适应症。IVM在辅助生殖技术中具有前景，涵盖从癌症患者生育力保存到治疗PCOS等应用。提高的妊娠率突出了其疗效，与IVF相比风险降低凸显了其重要性。需要进一步研究以在不同患者群体中实现最佳应用，重点是完善方案和扩大应用范围。
