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维甲素 A 通过诱导细胞凋亡和自噬性细胞死亡、产生内源性 ROS、使细胞周期阻滞于 G2/M 期,并靶向作用于 MAPK/RAS/RAF 信号通路,抑制顺铂耐药的人口腔癌细胞生长。

Inhibition of cancer cell growth in cisplatin-resistant human oral cancer cells by withaferin-A is mediated via both apoptosis and autophagic cell death, endogenous ROS production, G2/M phase cell cycle arrest and by targeting MAPK/RAS/RAF signalling pathway.

机构信息

Department of Stomatology, Affiliated Hospital of Chengde Medical University, Chengde 067000, China.

出版信息

J BUON. 2021 Mar-Apr;26(2):647.

PMID:34077031
Abstract

The Editors of JBUON issue an Expression of Concern to 'Inhibition of cancer cell growth in cisplatin-resistant human oral cancer cells by withaferin-A is mediated via both apoptosis and autophagic cell death, endogenous ROS production, G2/M phase cell cycle arrest and by targeting MAPK/RAS/RAF signalling pathway', by Xuelian Yin, Guang Yang, Dongjie Ma, Zhejun Su, JBUON 2020;25(1):332-337; PMID: 32277651. Following the publication of the above article, readers drew to our attention that part of the data was possibly unreliable. We sent emails to the authors with a request to provide the raw data to prove the originality, but received no reply. Therefore, as we continue to work through the issues raised, we advise readers to interpret the information presented in the article with due caution. We thank the readers for bringing this matter to our attention. We apologize for any inconvenience it may cause.

摘要

JBUON 杂志编辑就“铁皮枫斗晶通过调控 MAPK/ERK 信号通路抑制人胃癌 BGC-823 细胞的迁移和侵袭”一文发布关注声明,作者:胡成进,曹伟,解放军济南军区总医院检验科,JBUON 2012;17(2):175-178;PMID: 22370263。文章发表后,读者提请我们注意,部分数据可能不可靠。我们已向作者发邮件请求提供原始数据以证明其原创性,但尚未收到回复。因此,在我们继续处理所提出的问题的同时,我们建议读者在解读文章中的信息时应谨慎。我们感谢读者提出这一问题。对由此造成的任何不便,我们深表歉意。

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