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嘧啶核苷酸合成：体外淋巴细胞转化过程中的调控

Pyrimidine nucleotide synthesis: regulatory control during transformation of lymphocytes in vitro.

作者信息

Lucas Z J

出版信息

Science. 1967 Jun 2;156(3779):1237-40. doi: 10.1126/science.156.3779.1237.

DOI:10.1126/science.156.3779.1237
PMID:6025543
Abstract

The incorporation of uridine into RNA in lymphocytes undergoing transformation induced by phytohemagglutinin parallels its incorporation into the intratcellular pool of acid-soluble nucleotides and coincides with a 20-fold increase in the specific activity of uridine kinase. This increase is dependent upon synthesis of both RNA and protein and is subject to both repression and end-product inhibition by cytidine.

摘要

在由植物血凝素诱导发生转化的淋巴细胞中，尿苷掺入RNA的过程与其掺入细胞内酸溶性核苷酸池的过程相似，并且与尿苷激酶的比活性增加20倍相吻合。这种增加依赖于RNA和蛋白质的合成，并且受到胞苷的阻遏和终产物抑制。

相似文献

1
Pyrimidine nucleotide synthesis: regulatory control during transformation of lymphocytes in vitro.嘧啶核苷酸合成：体外淋巴细胞转化过程中的调控
Science. 1967 Jun 2;156(3779):1237-40. doi: 10.1126/science.156.3779.1237.
2
Uridine incorporation and RNA synthesis during stimulation of lymphocytes by PHA.
Exp Cell Res. 1970 Dec;63(2):411-21. doi: 10.1016/0014-4827(70)90230-2.
3
On the synthesis of RNA in lymphocytes stimulated by phytohemagglutinin. 1. Induction of uridine-kinase and the conversion of uridine to UTP.关于植物血凝素刺激的淋巴细胞中RNA的合成。1. 尿苷激酶的诱导及尿苷向UTP的转化。
Eur J Biochem. 1968 Apr;4(3):401-6. doi: 10.1111/j.1432-1033.1968.tb00226.x.
4
Pyrimidine nucleotide synthesis in the normal and hypertrophying rat heart. Relative importance of the de novo and "salvage" pathways.正常及肥大大鼠心脏中的嘧啶核苷酸合成。从头合成途径和“补救”途径的相对重要性。
Circ Res. 1970 Sep;27(3):415-28. doi: 10.1161/01.res.27.3.415.
5
[Coordination of the main and reutilization pathways of nucleotide biosynthesis in the lymphocytes in leukemia].[白血病淋巴细胞中核苷酸生物合成的主要途径与再利用途径的协调]
Vopr Med Khim. 1979 Nov-Dec;25(6):694-8.
6
Control of pyrimidine biosynthesis in human lymphocytes. Inhibition of pyrimidine biosynthesis de novo in phytohemagglutinin-stimulated lymphocytes by external uridine and its inhibition mechanism.人淋巴细胞中嘧啶生物合成的调控。外源性尿苷对植物血凝素刺激的淋巴细胞中嘧啶从头生物合成的抑制作用及其抑制机制。
J Biol Chem. 1973 Jul 10;248(13):4782-5.
7
Synthesis of nonribosomal RNA by lymphocytes: a response to phytohemagglutinin treatment.淋巴细胞合成非核糖体RNA：对植物血凝素处理的反应。
Science. 1966 Apr 22;152(3721):516-8. doi: 10.1126/science.152.3721.516.
8
[Effect of adenosine on synthesis of pyrimidine nucleotides and RNA in normal lymphocytes and under conditions of chronic lymphoid leukosis].[腺苷对正常淋巴细胞及慢性淋巴细胞白血病条件下嘧啶核苷酸和RNA合成的影响]
Vopr Med Khim. 1981 Mar-Apr;27(2):193-7.
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Effects of 5-mercapto-2'-deoxyuridine on the incorporation of nucleosides into RNA and DNA in a primary lymphocyte culture system.5-巯基-2'-脱氧尿苷对原代淋巴细胞培养系统中核苷掺入RNA和DNA的影响。
Cancer Res. 1976 Sep;36(9 pt.1):3284-93.
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Effects of 17 beta-estradiol on the incorporation of pyrimidine nucleotide precursors into nucleotide pools and RNA in the mouse uterus.17β-雌二醇对嘧啶核苷酸前体掺入小鼠子宫核苷酸池及RNA的影响。
Endocrinology. 1972 Mar;90(3):645-56. doi: 10.1210/endo-90-3-645.

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Nat Commun. 2019 Jul 11;10(1):3051. doi: 10.1038/s41467-019-11082-3.
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Cellular and molecular aspects of immune system aging.免疫系统衰老的细胞和分子层面
Mol Cell Biochem. 1981 Jul;37(3):137-56. doi: 10.1007/BF02354883.
3
Incorporation of [5-3H]uridine and attachment of cells to glass during activation of lymphocytes induced by phytohaemagglutinin.在植物血凝素诱导淋巴细胞活化过程中[5-3H]尿苷的掺入及细胞与玻璃的附着
Biochem J. 1968 Jun;108(2):297-302. doi: 10.1042/bj1080297.
4
Studies on lysosomes. XII. Redistribution of acid hydrolases in human lymphocytes stimulated by phytohemagglutinin.溶酶体研究。十二。植物血凝素刺激后人淋巴细胞中酸性水解酶的重新分布。
J Cell Biol. 1968 May;37(2):412-23. doi: 10.1083/jcb.37.2.412.
5
Kinetics of RNA synthesis in toad bladder epithelium: action of aldosterone during the latent period.蟾蜍膀胱上皮细胞中RNA合成的动力学：潜伏期醛固酮的作用
J Clin Invest. 1971 Mar;50(3):543-51. doi: 10.1172/JCI106523.
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[Lymphocyte stimulation by pokeweed mitogen (PWM)].[商陆丝裂原（PWM）对淋巴细胞的刺激作用]
Klin Wochenschr. 1969 Dec 15;47(24):1307-13. doi: 10.1007/BF01484293.
7
Studies on the incorporation of [5-3H] uridine during activation and transformation of lymphocytes induced by phytohaemagglutinin. Dependence on the incorporation rate on uridine concentration at certain critical concentrations.关于[5-3H]尿苷在植物血凝素诱导的淋巴细胞活化和转化过程中的掺入研究。在某些临界浓度下掺入率对尿苷浓度的依赖性。
Biochem J. 1968 Mar;107(2):197-205. doi: 10.1042/bj1070197.
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Inhibition of DNA synthesis by methylglyoxal bis(guanylhydrazone) during lymphocyte transformation.双胍乙腙在淋巴细胞转化过程中对DNA合成的抑制作用。
Mol Biol Rep. 1974 Dec;1(8):431-6. doi: 10.1007/BF00360667.
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Lymphopenic immunologic deficiency in identical twins: lymphocyte allografting and graft-versus-host disease following treatment with albumin-gradient-separated paternal bone marrow cells.同卵双胞胎的淋巴细胞减少性免疫缺陷：用白蛋白梯度分离的父本骨髓细胞治疗后的淋巴细胞同种异体移植和移植物抗宿主病
Clin Exp Immunol. 1971 Sep;9(3):289-304.
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Combined effects of phytohemagglutinin and staphylococcal enterotoxin B on deoxyribonucleic acid synthesis during blast transformation in human lymphocytes.植物血凝素和葡萄球菌肠毒素B对人淋巴细胞母细胞转化过程中脱氧核糖核酸合成的联合作用。
Infect Immun. 1974 Feb;9(2):384-90. doi: 10.1128/iai.9.2.384-390.1974.