Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Division of Neonatology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA.
Appl Physiol Nutr Metab. 2021 Nov;46(11):1363-1369. doi: 10.1139/apnm-2021-0248. Epub 2021 Jun 2.
We investigated the effect of daily intake of yogurt drink fortified with either vitamin D alone or with added calcium on resting metabolic rate (RMR), thyroid hormones and homeostatic model assessment for insulin resistance in subjects with type 2 diabetes (T2D). A total of 75 adult subjects with T2D were randomly assigned to 1 of the 3 groups to receive either D-fortified yogurt drink (DY; 1000 IU vitamin D/day), Ca-D-fortified yogurt drink (CDY; 1000 IU vitamin D plus 500 mg calcium), or plain yogurt drink for 12 weeks. All assessments were done at the baseline and after the intervention. The concentrations of anti-thyroid peroxidase antibody (anti-TPO-Ab), intact parathyroid hormone (iPTH) and thyroid stimulating hormone (TSH) had declined significantly compared with baseline values only in the CDY group. The mean RMR increased in both DY and CDY groups ( < 0.001 for both). Also, changes of serum concentrations of 25-hydroxycalciferol (B = 2.96, 95% confidence interval (CI) = 1.3 to 4.6, = 0.001) and iPTH (B = -2.41, 95% CI = -4.5 to -0.31, = 0.025) remained significant predictors of RMR changes even after adjustment for changes of serum concentrations of TSH (B = -18.2, 95% CI = -61.7 to 25.2, = 0.406). Daily intake of vitamin D together with calcium at physiological doses has attenuating effect on anti-TPO-Ab and TSH. Also, vitamin D with or without added calcium causes a significant thyroid-independent increase in RMR in euthyroid subjects with T2D. Registered at clinicaltrials.gov as NCT01229891. Daily intake of vitamin D with calcium at physiological doses has attenuating effect on anti-TPO-Ab and TSH. Vitamin D with or without added calcium causes a thyroid-independent increase in RMR in euthyroid subjects with T2D.
我们研究了每日摄入强化维生素 D 的酸奶或添加钙的酸奶对 2 型糖尿病（T2D）患者静息代谢率（RMR）、甲状腺激素和胰岛素抵抗的稳态模型评估（HOMA-IR）的影响。共有 75 名 T2D 成年受试者被随机分为 3 组，分别接受 D 强化酸奶（DY；每天 1000IU 维生素 D）、Ca-D 强化酸奶（CDY；每天 1000IU 维生素 D 加 500mg 钙）或普通酸奶，干预 12 周。所有评估均在基线和干预后进行。仅在 CDY 组中，与基线值相比，抗甲状腺过氧化物酶抗体（anti-TPO-Ab）、完整甲状旁腺激素（iPTH）和促甲状腺激素（TSH）的浓度明显下降。DY 和 CDY 组的平均 RMR 均增加（两者均 < 0.001）。此外，血清 25-羟维生素 D（B = 2.96，95%置信区间（CI）= 1.3 至 4.6，= 0.001）和 iPTH（B = -2.41，95%CI = -4.5 至 -0.31，= 0.025）浓度的变化仍然是 RMR 变化的显著预测因子，即使在调整血清 TSH 浓度变化后（B = -18.2，95%CI = -61.7 至 25.2，= 0.406）。生理剂量的维生素 D 与钙的每日摄入对 anti-TPO-Ab 和 TSH 具有减弱作用。此外，维生素 D 加或不加钙可导致甲状腺功能正常的 T2D 患者的 RMR 显著增加。在 clinicaltrials.gov 上注册为 NCT01229891。生理剂量的维生素 D 与钙的每日摄入对 anti-TPO-Ab 和 TSH 具有减弱作用。维生素 D 加或不加钙可导致甲状腺功能正常的 T2D 患者的 RMR 显著增加。
