每日摄入添加维生素 D 的酸奶饮料（添加或不添加钙）对 2 型糖尿病成年受试者血清脂联素和 Sirtuins 1 和 6 的影响。
The effect of daily intake of vitamin D-fortified yogurt drink, with and without added calcium, on serum adiponectin and sirtuins 1 and 6 in adult subjects with type 2 diabetes.
机构信息
Laboratory of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Division of Neonatology, Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
出版信息
Nutr Diabetes. 2021 Jul 30;11(1):26. doi: 10.1038/s41387-021-00168-x.
BACKGROUND
Some evidence suggests indirect ameliorating effects of vitamin D in diabetes via adiponectin and sirtuins. This study aimed to evaluate the effects of daily intake of vitamin D-fortified yogurt drink, either with or without added calcium, on serum adiponectin, sirtuins (SIRT)1 and 6.
METHODS
Briefly, 75 adults aged 30-60 years from both sexes with type 2 diabetes were randomly allocated to one of the three groups: (i) D-fortified-yogurt drink (DY; containing 1000 IU vitamin D and 300 mg calcium), (ii) Ca+D-fortified-yogurt drink (CDY; containing 1000 IU vitamin D and 500 mg calcium) and (iii) plain yogurt drink (PY; containing no detectable vitamin D and 300 mg calcium). All assessments were performed initially and after 12 weeks.
RESULTS
A significant within-group increment in serum adiponectin concentrations was observed in both DY and CDY groups (+60.4 ± 8.6, +57.5 ± 6.4 µg/L, respectively; p < 0.001 for both). The concentrations of SIRT1 and SIRT6 had a significant within-group increment only in the CDY group (p = 0.003, p = 0.001 respectively). Being in CDY group was more favorable predictor of improvement in SIRT6 concentrations. Changes of 25(OH)D were a significant predictor of changes of adiponectin. However, this association disappeared following adjustment for changes of SIRT1. In contrast, the association between changes of 25(OH)D and HbA1c remained significant even after adjustment for SIRT1.
CONCLUSIONS
Daily consumption of vitamin D-fortified yogurt drink for 12 weeks resulted in an increase in circulating concentrations of SIRT1 and SIRT6 in T2D subjects and D+Ca-fortified yogurt drink was more in favor of SIRT6 increment.
背景
一些证据表明，维生素 D 通过脂联素和沉默调节蛋白间接改善糖尿病。本研究旨在评估每日摄入强化维生素 D 的酸奶饮料（添加或不添加钙）对血清脂联素、沉默调节蛋白（SIRT）1 和 6 的影响。
方法
简要地，75 名年龄在 30-60 岁之间的 2 型糖尿病成年男女患者被随机分配到以下三组之一：（i）强化维生素 D 的酸奶饮料（DY；含有 1000IU 维生素 D 和 300mg 钙），（ii）添加钙的强化维生素 D 酸奶饮料（CDY；含有 1000IU 维生素 D 和 500mg 钙）和（iii）普通酸奶饮料（PY；不含可检测的维生素 D 和 300mg 钙）。所有评估均在初始时和 12 周后进行。
结果
在 DY 和 CDY 组中，血清脂联素浓度均出现显著的组内增加（分别为+60.4±8.6、+57.5±6.4μg/L；p<0.001）。仅在 CDY 组中，SIRT1 和 SIRT6 的浓度出现显著的组内增加（p=0.003，p=0.001）。在 CDY 组中，SIRT6 浓度的改善更有利于预测。25（OH）D 的变化是脂联素变化的显著预测因素。然而，这种关联在调整 SIRT1 变化后消失。相比之下，即使在调整 SIRT1 后，25（OH）D 与 HbA1c 之间的关联仍然显著。
结论
12 周内每日摄入强化维生素 D 的酸奶饮料可增加 2 型糖尿病患者循环中 SIRT1 和 SIRT6 的浓度，D+Ca 强化酸奶饮料更有利于 SIRT6 增加。
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