Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China; National Research Institute for Family Planning, Beijing, China.
Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China; Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China; Department of Gynecology and Obstetrics, Peking University Third Hospital, Beijing, China.
Environ Res. 2021 Sep;200:111399. doi: 10.1016/j.envres.2021.111399. Epub 2021 May 30.
Limited evidence is known about whether long-term exposures to air borne particulate matters of 2.5 μm or less (PM) impact human hematologic index for women preparing for pregnancy. No study assessed the effect of PM, which is small enough to reach the blood circulation.
To evaluate whether exposure to PM and PM is associated with blood cell count of woman preparing for pregnancy.
Based on the baseline data of a national birth cohort in China, we analysed the white blood cell (WBC), red blood cells (RBC) and thrombocyte counts of 1,203,565 women who are aged 18-45 years, being Han ethnicity, had no chronic disease and preparing for pregnancy. We matched their home addresses and examination date with daily concentrations of PM and PM which were estimated by a machine learning method with remote sensing, meteorological and land use information. Generalized additive mixed model to examine the associations between exposure to one-year average exposure to PMs prior to the health examination and the blood cells counts, after adjustment for potential individual variables.
A 10 μg/m PM increment was associated with -1.49% (95%CI: 1.56%, -1.42%) difference in WBC count; with 0.33% (95%CI: 0.30%, 0.36%) difference of RBC count; and with 1.08% (95%CI: 1.01%, 1.15%) difference of thrombocyte count. For PM, the corresponding difference was -0.47% (95%CI: 0.54%, -0.39%) for WBC; was 0.06% (95%CI: 0.03%, 0.09%) for RBC; and was 1.10% (95%CI: 1.02%, 1.18%) for thrombocyte. Women working as workers, being overweight and with tobacco smoking exposure had higher associations between PMs and hematologic index than their counterparts (p < 0.05 for interaction test).
Long-term exposure to PMs were associated with decrement in WBC, as well as increment in RBC and thrombocytes among Han Chinese women preparing for pregnancy. Measures such as using air purifiers and wearing a mask in polluted areas should be improved to prevent women from the impact of PMs.
目前已知的证据有限，无法确定长期暴露于空气中直径 2.5μm 或以下的颗粒物（PM）是否会影响准备怀孕的女性的血液学指标。没有研究评估 PM 的影响，因为 PM 小到足以进入血液循环。
评估 PM 和 PM 暴露与准备怀孕的女性血细胞计数之间的关系。
基于中国一个全国性出生队列的基线数据，我们分析了 1203565 名年龄在 18-45 岁、汉族、没有慢性疾病且正在备孕的女性的白细胞（WBC）、红细胞（RBC）和血小板计数。我们将她们的家庭住址和检查日期与通过机器学习方法利用遥感、气象和土地利用信息估算的每日 PM 和 PM 浓度进行匹配。采用广义加性混合模型，在调整潜在个体变量后，检验健康检查前一年平均暴露于 PMs 与血细胞计数之间的关系。
PM 浓度每增加 10μg/m³，WBC 计数减少 1.49%（95%CI：1.56%，1.42%）；RBC 计数减少 0.33%（95%CI：0.30%，0.36%）；血小板计数增加 1.08%（95%CI：1.01%，1.15%）。对于 PM，WBC 的相应差异为-0.47%（95%CI：0.54%，-0.39%）；RBC 为 0.06%（95%CI：0.03%，0.09%）；血小板为 1.10%（95%CI：1.02%，1.18%）。与其他职业相比，工人、超重和有吸烟暴露的女性 PMs 与血液学指标之间的关联更高（交互检验 p<0.05）。
长期暴露于 PMs 与准备怀孕的汉族女性的 WBC 减少以及 RBC 和血小板增加有关。应采取措施，如在污染地区使用空气净化器和戴口罩，以防止妇女受到 PMs 的影响。
