Department of Gynecology and Obstetrics, Peking University Third Hospital, Beijing, China; Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China; Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China.
Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China; National Research Institute for Family Planning, Beijing, China.
Environ Int. 2021 Feb;147:106348. doi: 10.1016/j.envint.2020.106348. Epub 2020 Dec 30.
Limited studies have examined the impact of airborne particulate matter of 2.5 μm or less (PM) on renal function. No study has examined the effect of PM, which is small enough to reach the blood circulation. We examined whether exposure to PM or PM affected renal function of young Han Chinese.
We included 2,546,047 young adults who were aged 18 to 45 years, being Han ethnicity and had no chronic disease from a Chinese national birth cohort. Serum creatinine (Scr) of each participant was measured during the baseline examination. Estimated glomerular filtration rate (eGFR) were calculated for each participant using the latest Chronic Kidney Disease Epidemiology Collaboration equation. One-year average exposure to PM and PM prior to the health examination for each participant were estimated using machine learning models with satellite remote sensing information. Generalized additive mixed models were used to estimate associations between PM or PM and renal function after adjusting for detailed individual variables.
A 10 μg/m increment in PM exposure was associated with -0.95% (95%CI: -1.04%, -0.87%) difference of eGFR in females and -0.37% (95%CI: -0.44%, -0.31%) in males. For PM, the corresponding difference of eGFR was -0.99% (95%CI: -1.05%, -0.93%) in females and -0.48% (95%CI: -0.53%, -0.43%) in males, respectively. Associations between eGFR and PM were higher in females compared to males (p < 0.05 for interaction test). Association with PM were weaker than that with other fractions included in PM. Participants who worked as farmers, were of normal weight, were not exposed to tobacco smoking, did not drink alcohol, had higher associations between eGFR and PM than their counterparts (p < 0.05 for interaction test).
Exposure to PM and PM was associated with reduced renal function among Han Chinese at reproductive age.
有限的研究考察了 2.5μm 或更小粒径的空气悬浮颗粒物（PM）对肾功能的影响。尚无研究考察 PM 的影响，因为 PM 小到足以进入血液循环。我们研究了暴露于 PM 或 PM 是否会影响年轻汉族人的肾功能。
我们纳入了 2546047 名年龄在 18 至 45 岁之间的汉族青年成年人，他们没有慢性病，来自中国一个全国性的出生队列。在基线检查期间，每位参与者的血清肌酐（Scr）都被测量。根据最新的慢性肾脏病流行病学合作研究组方程，为每位参与者计算估计肾小球滤过率（eGFR）。使用基于卫星遥感信息的机器学习模型，估算每位参与者在健康检查前一年的 PM 和 PM 平均暴露量。使用广义加性混合模型，在调整详细个体变量后，估计 PM 或 PM 与肾功能之间的关联。
PM 暴露量每增加 10μg/m，女性 eGFR 降低 0.95%（95%CI：-1.04%，-0.87%），男性降低 0.37%（95%CI：-0.44%，-0.31%）。对于 PM，女性 eGFR 的相应差异为-0.99%（95%CI：-1.05%，-0.93%），男性为-0.48%（95%CI：-0.53%，-0.43%）。与 eGFR 相比，女性与 PM 之间的关联高于男性（交互检验 p<0.05）。与 PM 的关联比与 PM 中包含的其他部分的关联弱。与对照组相比，从事农业工作、体重正常、不接触吸烟、不饮酒的参与者与 PM 之间的 eGFR 关联更高（交互检验 p<0.05）。
在生殖年龄段的汉族人群中，暴露于 PM 和 PM 与肾功能下降有关。
