斯堪的纳维亚母婴队列研究中妊娠中期和分娩时的母体人乳头瘤病毒感染。
Maternal human papillomavirus infections at mid-pregnancy and delivery in a Scandinavian mother-child cohort study.
机构信息
Department of Obstetrics and Gynecology, Østfold Hospital Trust, Kalnes, Norway; University of Oslo, Faculty of Medicine, Institute of Clinical Medicine, Oslo, Norway.
Department of Obstetrics and Gynecology, Østfold Hospital Trust, Kalnes, Norway; Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
出版信息
Int J Infect Dis. 2021 Jul;108:574-581. doi: 10.1016/j.ijid.2021.05.064. Epub 2021 May 30.
OBJECTIVES
Human papillomavirus (HPV) infections are common, especially during women's reproductive years, with unclear obstetrical impact. This study aimed to identify HPV prevalence at mid-gestation and delivery, type-specific persistence from mid-gestation to delivery, and risk factors for HPV infection and persistence.
METHODS
In 757 women from a Scandinavian prospective mother-child cohort, HPV was analyzed in first-void urine samples at mid-gestation and delivery. We used Seegene Anyplex II HPV28 PCR assay for genotyping and semi-quantifying 28 genital HPV genotypes, including 12 high-risk HPVs (HR-HPV). Socio-demographic and health data were collected through e-questionnaires.
RESULTS
Any-HPV genotype (any of 28 assessed) was detected in 38% of the study cohort at mid-gestation and 28% at delivery, and HR-HPVs in 24% and 16%, respectively. The most prevalent genotype was HPV16: 6% at mid-gestation and 4% at delivery. Persistence of Any-HPV genotype was 52%, as was HR-HPV genotype-specific persistence. A short pre-conception relationship with the child's father and alcohol intake during pregnancy increased HPV infection risk at both time points. Low viral load at mid-gestation was associated with clearance of HPV infections at delivery.
CONCLUSION
HPV prevalence was higher at mid-gestation compared with delivery, and low viral load was associated with clearance of HPV at delivery.
目的
人乳头瘤病毒（HPV）感染较为常见，尤其是在女性生育期，但其对产科的影响尚不清楚。本研究旨在确定妊娠中期和分娩时 HPV 的流行率、从中孕期到分娩时特定型别的持续性，以及 HPV 感染和持续性的危险因素。
方法
在一个来自斯堪的纳维亚前瞻性母婴队列的 757 名女性中，在妊娠中期和分娩时，使用首次排空尿液样本检测 HPV。我们使用 Seegene Anyplex II HPV28 PCR 检测法进行基因分型，并对半定量分析 28 种生殖 HPV 基因型，包括 12 种高危 HPV（HR-HPV）。通过电子问卷收集社会人口统计学和健康数据。
结果
在妊娠中期和分娩时，研究队列中分别有 38%和 28%检测到任何 HPV 基因型（28 种评估的任何一种），分别有 24%和 16%检测到 HR-HPVs。最常见的基因型是 HPV16：妊娠中期为 6%，分娩时为 4%。任何 HPV 基因型的持续性为 52%，HR-HPV 基因型特异性持续性也是如此。妊娠中期与孩子父亲的短暂恋爱关系和怀孕期间饮酒会增加两个时间点的 HPV 感染风险。妊娠中期低病毒载量与分娩时 HPV 感染清除有关。
结论
与分娩时相比，妊娠中期 HPV 的流行率更高，低病毒载量与分娩时 HPV 的清除有关。
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