爱泼斯坦-巴尔病毒LMP1相互作用组：生物学意义与治疗靶点
The Epstein-Barr virus LMP1 interactome: biological implications and therapeutic targets.
作者信息
Cheerathodi Mujeeb R, Meckes David G
机构信息
Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, 32306.
出版信息
Future Virol. 2018 Dec;13(12):863-887. doi: 10.2217/fvl-2018-0120. Epub 2018 Dec 3.
Abstract
The oncogenic potential of Epstein-Barr virus (EBV) is mostly attributed to latent membrane protein 1 (LMP1), which is essential and sufficient for transformation of fibroblast and primary lymphocytes. LMP1 expression results in the activation of multiple signaling cascades like NF-ΚB and MAP kinases that trigger cell survival and proliferative pathways. LMP1 specific signaling events are mediated through the recruitment of a number of interacting proteins to various signaling domains. Based on these properties, LMP1 is an attractive target to develop effective therapeutics to treat EBV-related malignancies. In this review, we focus on LMP1 interacting proteins, associated signaling events, and potential targets that could be exploited for therapeutic strategies.
摘要
爱泼斯坦-巴尔病毒（EBV）的致癌潜力主要归因于潜伏膜蛋白1（LMP1），它对于成纤维细胞和原代淋巴细胞的转化至关重要且足够。LMP1的表达导致多种信号级联反应的激活，如NF-ΚB和MAP激酶，这些级联反应触发细胞存活和增殖途径。LMP1特异性信号事件是通过招募多种相互作用蛋白到不同的信号结构域来介导的。基于这些特性，LMP1是开发治疗EBV相关恶性肿瘤有效疗法的一个有吸引力的靶点。在这篇综述中，我们重点关注LMP1相互作用蛋白、相关信号事件以及可用于治疗策略的潜在靶点。
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