一种用于在创伤性脑损伤的液压冲击动物模型中定量评估脑灌注压的新型无线光学技术。
A novel wireless optical technique for quantitative evaluation of cerebral perfusion pressure in a fluid percussion animal model of traumatic brain injury.
作者信息
Huang Yao-Kuang, Lin Chin-Kuo, Wang Che-Chuan, Kuo Jinn-Rung, Lai Chien-Fu, Chen Chien-Wei, Lin Bor-Shyh
机构信息
Division of Cardiovascular Surgery and Radiology, Chiayi Chang Gung Memorial Hospital, Putz, Chiayi.
College of Medicine, Chang Gung University, Taoyuan.
出版信息
Quant Imaging Med Surg. 2021 Jun;11(6):2388-2396. doi: 10.21037/qims-20-777.
BACKGROUND
Cerebral perfusion pressure (CPP) calculated by mean arterial pressure (MAP) minus intracranial pressure (ICP) is related to blood flow into the brain and reflects cerebral ischemia and oxygenation indirectly. Near-infrared spectroscopy (NIRS) can assess cerebral ischemia and hypoxia non-invasively and has been widely used in neuroscience. However, the correlation between CPP and NIRS, and its potential application in traumatic brain injury, has seldom been investigated.
METHODS
We used a novel wireless NIRS system and commercial ICP and MAP devices to assess the trauma to rat brains using different impact intensity. The relationship between CPP and NIRS parameters with increasing impact strength were investigated.
RESULTS
The results showed that changes in CPP (∆CPP), oxy-hemoglobin {∆[HbO]}, total-hemoglobin {∆[HbT]}, and deoxy-hemoglobin were inversely proportional to the increase in impact intensity, and the correlations between ∆CPP, NIRS parameters {∆[HbO], and ∆[HbT]} were significant.
CONCLUSIONS
The NIRS system can assess cerebral ischemia and oxygenation non-invasively and changes of HbO and HbT may be used as reference parameters to assess the level of CPP in an animal model of traumatic brain injury.
背景
通过平均动脉压（MAP）减去颅内压（ICP）计算得出的脑灌注压（CPP）与脑血流量相关，并间接反映脑缺血和氧合情况。近红外光谱（NIRS）可无创评估脑缺血和缺氧情况，已在神经科学领域广泛应用。然而，CPP与NIRS之间的相关性及其在创伤性脑损伤中的潜在应用鲜有研究。
方法
我们使用一种新型无线NIRS系统以及商用ICP和MAP设备，通过不同的撞击强度评估大鼠脑损伤情况。研究了随着撞击强度增加，CPP与NIRS参数之间的关系。
结果
结果显示，CPP的变化（∆CPP）、氧合血红蛋白{∆[HbO]}、总血红蛋白{∆[HbT]}和脱氧血红蛋白与撞击强度的增加呈反比，且∆CPP与NIRS参数{∆[HbO]和∆[HbT]}之间的相关性显著。
结论
NIRS系统可无创评估脑缺血和氧合情况，HbO和HbT的变化可作为创伤性脑损伤动物模型中评估CPP水平的参考参数。
Zotero 插件