利用光学技术评估创伤性脑损伤。
Evaluation of traumatic brain injury by optical technique.
作者信息
Lin Bor-Shyh, Wang Che-Chuan, Chang Ming-Hsien, Chio Chung-Ching
机构信息
Institute of Imaging and Biomedical Photonics, National Chiao-Tung University, Tainan, Taiwan.
Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
出版信息
BMC Neurol. 2015 Oct 14;15:202. doi: 10.1186/s12883-015-0465-3.
BACKGROUND
Traumatic brain injury (TBI), usually due to brain shaking or impact, affects the normal brain function and may lead to severe disability or even death. However, there is paucity of information regarding changes in the physiologic state of humans or animals after brain shaking.
METHODS
In this study, near-infrared spectroscopy (NIRS) was used to continuously monitor the concentration change of oxy-hemoglobin (HbO2) and deoxy-hemoglobin (HbR) to understand changes in the physiological state during and after brain shaking. Laser Doppler flowmetry was also used to monitor changes in cerebral blood flow under TBI to supplement the investigation. Triphenyltetrazolium chloride (TTC) staining was used to monitor changes of infarction volume corresponding to different impact strengths.
RESULT
The experimental results indicated that concentration changes of HbO2 and total-hemoglobin (HbT) were significantly related to the impact strength. The infarction volume was also significantly related to the impact strength.
CONCLUSION
Therefore, the non-invasive monitoring of concentration changes in HbO 2 , HbR, and HbT using NIRS may have a clinical application for the evaluation of TBI.
背景
创伤性脑损伤（TBI）通常由脑部震荡或撞击引起，会影响大脑正常功能，并可能导致严重残疾甚至死亡。然而，关于脑部震荡后人类或动物生理状态变化的信息却很匮乏。
方法
在本研究中，使用近红外光谱（NIRS）连续监测氧合血红蛋白（HbO2）和脱氧血红蛋白（HbR）的浓度变化，以了解脑部震荡期间及之后的生理状态变化。还使用激光多普勒血流仪监测创伤性脑损伤情况下的脑血流变化，以补充研究。采用氯化三苯基四氮唑（TTC）染色来监测对应不同撞击强度的梗死体积变化。
结果
实验结果表明，HbO2和总血红蛋白（HbT）的浓度变化与撞击强度显著相关。梗死体积也与撞击强度显著相关。
结论
因此，使用NIRS对HbO2、HbR和HbT浓度变化进行无创监测可能在创伤性脑损伤评估中具有临床应用价值。
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