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Serum MicroRNA-155 in Acute Graft-Versus-Host-Disease (aGVHD).

作者信息

Efebera Yvonne A, Ruppert Amy S, Ngankeu Apollinaire, Garman Sabrina, Kumchala Prasanthi, Howard Alan, Devine Steven M, Ranganathan Parvathi, Garzon Ramiro

机构信息

Division of Hematology, Department of Internal Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.

Blood and Marrow Transplant Clinical Trial Network, National Marrow Donor Program, USA.

出版信息

Int J Bone Marrow Res. 2019;2:079-82. doi: 10.29328/journal.ijbmr.1001007. Epub 2019 Aug 16.

DOI:10.29328/journal.ijbmr.1001007
PMID:34079960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8168723/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d3e/8168723/03e762421c05/nihms-1573590-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d3e/8168723/03e762421c05/nihms-1573590-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d3e/8168723/03e762421c05/nihms-1573590-f0001.jpg

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2
miR-153-3p, a new bio-target, is involved in the pathogenesis of acute graft-versus-host disease via inhibition of indoleamine- 2,3-dioxygenase.微小RNA-153-3p作为一种新的生物靶点，通过抑制吲哚胺2,3-双加氧酶参与急性移植物抗宿主病的发病机制。
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Endothelial microparticles delivering microRNA-155 into T lymphocytes are involved in the initiation of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.携带微小RNA-155的内皮微粒进入T淋巴细胞，参与异基因造血干细胞移植后急性移植物抗宿主病的发生。
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[Correlation between Plasma microRNA Expression and Acute Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation].[异基因造血干细胞移植后血浆微小RNA表达与急性移植物抗宿主病的相关性]
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本文引用的文献

1
The Role of Biomarkers in the Diagnosis and Risk Stratification of Acute Graft-versus-Host Disease: A Systematic Review.生物标志物在急性移植物抗宿主病诊断和风险分层中的作用：一项系统综述
Biol Blood Marrow Transplant. 2016 Sep;22(9):1552-1564. doi: 10.1016/j.bbmt.2016.04.022. Epub 2016 May 5.
2
miR-146a and miR-155 Expression Levels in Acute Graft-Versus-Host Disease Incidence.急性移植物抗宿主病发生率中miR-146a和miR-155的表达水平
Front Immunol. 2016 Mar 8;7:56. doi: 10.3389/fimmu.2016.00056. eCollection 2016.
3
Plasma microRNA-586 is a new biomarker for acute graft-versus-host disease.
血浆微小RNA-586是急性移植物抗宿主病的一种新生物标志物。
Ann Hematol. 2015 Sep;94(9):1505-14. doi: 10.1007/s00277-015-2414-z. Epub 2015 Jun 9.
4
MicroRNA-155-deficient dendritic cells cause less severe GVHD through reduced migration and defective inflammasome activation.miR-155 缺陷树突状细胞通过减少迁移和缺陷炎性体激活导致 GVHD 减轻。
Blood. 2015 Jul 2;126(1):103-12. doi: 10.1182/blood-2014-12-617258. Epub 2015 May 13.
5
The IL-33/ST2 axis augments effector T-cell responses during acute GVHD.白细胞介素-33/ST2轴在急性移植物抗宿主病期间增强效应T细胞反应。
Blood. 2015 May 14;125(20):3183-92. doi: 10.1182/blood-2014-10-606830. Epub 2015 Mar 26.
6
Serum microRNA155 is increased in patients with acute graft-versus-host disease.急性移植物抗宿主病患者血清微小RNA155水平升高。
Clin Transplant. 2014 Mar;28(3):314-23. doi: 10.1111/ctr.12314. Epub 2014 Feb 4.
7
Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease.血浆 microRNA 特征可作为急性移植物抗宿主病的无创性生物标志物。
Blood. 2013 Nov 7;122(19):3365-75. doi: 10.1182/blood-2013-06-510586. Epub 2013 Sep 16.
8
ST2 as a marker for risk of therapy-resistant graft-versus-host disease and death.ST2 可作为治疗抵抗性移植物抗宿主病和死亡的标志物。
N Engl J Med. 2013 Aug 8;369(6):529-39. doi: 10.1056/NEJMoa1213299.
9
Discovery and validation of graft-versus-host disease biomarkers.移植物抗宿主病生物标志物的发现和验证。
Blood. 2013 Jan 24;121(4):585-94. doi: 10.1182/blood-2012-08-355990. Epub 2012 Nov 19.
10
Advances in graft-versus-host disease biology and therapy.移植物抗宿主病生物学和治疗的进展。
Nat Rev Immunol. 2012 May 11;12(6):443-58. doi: 10.1038/nri3212.