Atarod Sadaf, Ahmed Mohammed Mahid, Lendrem Clare, Pearce Kim Frances, Cope Wei, Norden Jean, Wang Xiao-Nong, Collin Matthew, Dickinson Anne Mary
Haematological Sciences, Institute of Cellular Medicine, Newcastle University , Newcastle upon Tyne , UK.
Front Immunol. 2016 Mar 8;7:56. doi: 10.3389/fimmu.2016.00056. eCollection 2016.
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment for numerous hematological malignancies. However, acute graft-versus-host disease (aGVHD) is still the major complication causing mortality. MicroRNAs (miRNAs) play a significant role in inflammation and have potential as prognostic and diagnostic biomarkers. This study investigated the role of two immune-specific miRNAs (miR-146a and miR-155) as biomarkers for aGVHD incidence in the peripheral blood of allo-HSCT patients prior to disease onset. The study showed that miR-146a and its statistical interaction with miR-155 at day +28 were predictive of aGVHD incidence. Interestingly, the expression levels of miR-146a and miR-155 negatively correlated with the transcription factor, SPI1 (PU.1gene) mRNA expression.
异基因造血干细胞移植（allo-HSCT）是治疗多种血液系统恶性肿瘤的一种治愈性疗法。然而，急性移植物抗宿主病（aGVHD）仍然是导致死亡的主要并发症。微小RNA（miRNA）在炎症中发挥重要作用，并且有作为预后和诊断生物标志物的潜力。本研究调查了两种免疫特异性miRNA（miR-146a和miR-155）作为疾病发作前allo-HSCT患者外周血中aGVHD发生率生物标志物的作用。研究表明，miR-146a及其在第28天时与miR-155的统计相互作用可预测aGVHD的发生率。有趣的是，miR-146a和miR-155的表达水平与转录因子SPI1（PU.1基因）mRNA表达呈负相关。
