在治疗过程中，产碳青霉烯酶阴沟肠杆菌对头孢他啶的耐药性迅速发展与儿茶酚载体铁载体受体 cirA 中的异质性突变有关。
Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA.
机构信息
Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, Heidelberg,Germany.
Department of Anesthesiology, Heidelberg University Hospital, Heidelberg,Germany.
出版信息
Clin Infect Dis. 2022 Mar 9;74(5):905-908. doi: 10.1093/cid/ciab511.
We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.
我们报告了一例患者在接受头孢地尔治疗 21 天内，出现对产碳青霉烯酶阴沟肠杆菌引起的腹腔内和血流感染的头孢地尔耐药的情况。全基因组测序显示，编码儿茶酚载体 siderophore 受体的 cirA 基因存在异质性突变，赋予了对头孢地尔的表型耐药性。
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