WATCHMAN植入术后出现对头孢地尔耐药的菌血症：一例病例报告及文献综述
Cefiderocol-Resistant Bacteremia Following WATCHMAN Implantation: A Case Report and Review of the Literature.
作者信息
DeFrank Anna, Bosco Michael, Muñoz Gómez Sigridh, Dhaliwal Amit
机构信息
Department of Pharmacy, NYU Langone Hospital - Long Island, Mineola, New York, USA.
Department of Medicine, Division of Infectious Disease, NYU Grossman Long Island School of Medicine, Mineola, New York, USA.
出版信息
Case Rep Infect Dis. 2025 May 20;2025:5221364. doi: 10.1155/crdi/5221364. eCollection 2025.
is an emerging pathogen associated with nosocomial and community outbreaks. Treatment of infection caused by is not well-defined given its extensive drug resistance profile, and infection carries a poor prognosis. is intrinsically resistant to many classes of antibiotics including carbapenems and polymyxins due to multiple resistance genes. Resistance to novel β-lactam/β-lactamase inhibitors has also been reported. The activity of cefiderocol (FDC) is unknown. Here, we describe a case of FDC-resistant bacteremia following WATCHMAN implantation. To our knowledge, this is the first reported case of FDC resistance amongst spp.
是一种与医院和社区暴发相关的新兴病原体。鉴于其广泛的耐药谱，由其引起的感染治疗尚不明确，且感染预后较差。由于多种耐药基因，其对包括碳青霉烯类和多粘菌素类在内的许多类抗生素具有内在耐药性。也有对新型β-内酰胺/β-内酰胺酶抑制剂耐药的报道。头孢地尔（FDC）的活性未知。在此，我们描述了一例在植入WATCHMAN后发生的对FDC耐药的菌血症病例。据我们所知，这是首次报道的在 菌属中对FDC耐药的病例。
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