微小RNA诱导沉默复合体保护结肠干细胞免受炎症损伤。
MRISCs protect colonic stem cells from inflammatory damage.
作者信息
Zhu Guoli, Xi Rongwen
机构信息
National Institute of Biological Sciences, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China.
Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China.
出版信息
Cell Regen. 2021 Jun 3;10(1):24. doi: 10.1186/s13619-021-00086-4.
Increasing evidence suggest functional roles of subepithelial mesenchymal niche cells in maintaining intestinal stem cells and in modulating the pathogenesis of various intestinal diseases in mammals. A recent study reported the discovery of a new population of stromal cells in mice termed MAP3K2-Regulated Intestinal Stromal Cells (MRISCs); these cells reside at the base of colonic crypt and function to protect colonic stem cells during colonic inflammation by expressing the Wnt agonist R-spondin1 (Rspo1).
越来越多的证据表明，上皮下间充质生态位细胞在维持肠道干细胞以及调节哺乳动物各种肠道疾病的发病机制中发挥着功能作用。最近一项研究报告称，在小鼠中发现了一种新的基质细胞群，称为MAP3K2调节的肠道基质细胞（MRISCs）；这些细胞位于结肠隐窝底部，在结肠炎症期间通过表达Wnt激动剂R-spondin1（Rspo1）来保护结肠干细胞。
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