You Yee Xing, Shahar Suzana, Mohamad Mazlyfarina, Rajab Nor Fadilah, Haron Hasnah, Che Din Normah, Abdul Hamid Hamzaini
Dietetics Program and Center for Healthy Aging and Wellness (H-Care), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Diagnostic Imaging and Radiotherapy Program, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
J Magn Reson Imaging. 2021 Dec;54(6):1804-1818. doi: 10.1002/jmri.27762. Epub 2021 Jun 3.
Cosmos caudatus (CC) is traditional Asian vegetable, commonly consumed among the Southeast Asian population. It has been reported to be high in flavonoids and might potentially improve brain activity among older adults with mild cognitive impairment (MCI). The effect of CC in brain activation improvement using neuroimaging is yet to be discovered.
To investigate the effects of CC supplement on brain activity using functional magnetic resonance imaging (fMRI) among older adults with MCI.
Prospective, randomized, double-blind, placebo-controlled trial.
POPULATION/SUBJECTS: Twenty older adults with mild cognitive impairment (60-75 years old), 14 of them (70%) were female subjects.
FIELD STRENGTH/SEQUENCE: A 3.0-T, T1-weighted anatomical images, T2*-weighted imaging data, A single shot, gradient echo-echo planar imaging (EPI) sequence.
All subjects were asked to consume two 500 mg capsules of either CC supplement or placebo (maltodextrin) daily for 12 weeks. Cognitive function was measured using validated neuropsychological tests (i.e. Mini-mental State Examination and Digit Span) and task-based fMRI (N-back and Stroop Color Word Test) at baseline and 12th week. Brodmann's area 9, 46 and anterior cingulate cortex were selected as the regions of interest to define dorsolateral prefrontal cortex (DLPFC) in fMRI analysis.
Normality test was performed with the Shapiro-Wilk test. Two-way repeated ANOVA determined the intervention effects of the CC supplementation on brain activity after adjustments for covariates. Significance level at P < 0.05 for independent-t test and Chi square test; adjusted P < 0.0042 for two-way repeated ANOVA after Bonferroni correction.
Findings showed significant improvements in digit span (partial η = 0.559), increment in right DLPFC activation while performing 1-back task (partial η = 0.586) and left DLPFC activation while performing Stroop Color Word Test (SCWT) (congruent) task (partial η = 0.432) at 12th week of CC supplementation.
CC supplementation might have the ability to improve DLPFC activation, potentially leading to improved working memory among older adults with MCI after 12 weeks of administration.
1 TECHNICAL EFFICACY: Stage 4.
白凤菜是一种传统的亚洲蔬菜，在东南亚人群中普遍食用。据报道，它富含黄酮类化合物，可能会改善轻度认知障碍（MCI）老年人的脑活动。使用神经影像学研究白凤菜在改善脑激活方面的作用尚未被发现。
使用功能磁共振成像（fMRI）研究白凤菜补充剂对MCI老年人脑活动的影响。
前瞻性、随机、双盲、安慰剂对照试验。
20名轻度认知障碍的老年人（60 - 75岁），其中14名（70%）为女性。
场强/序列：3.0T，T1加权解剖图像，T2*加权成像数据，单次激发梯度回波 - 回波平面成像（EPI）序列。
所有受试者被要求每天服用两粒500毫克的白凤菜补充剂胶囊或安慰剂（麦芽糊精），持续12周。在基线和第12周时，使用经过验证的神经心理学测试（即简易精神状态检查表和数字广度测试）以及基于任务的fMRI（N - 回溯和Stroop颜色词测试）测量认知功能。在fMRI分析中，选择布罗德曼9区、46区和前扣带回皮质作为感兴趣区域来定义背外侧前额叶皮质（DLPFC）。
使用Shapiro - Wilk检验进行正态性检验。双向重复方差分析在对协变量进行调整后确定白凤菜补充剂对脑活动的干预效果。独立t检验和卡方检验的显著性水平为P < 0.05；经Bonferroni校正后，双向重复方差分析的校正P < 0.0042。
研究结果显示，在补充白凤菜12周时，数字广度有显著改善（偏η = 0.559），在进行1 - 回溯任务时右侧DLPFC激活增加（偏η = 0.586），在进行Stroop颜色词测试（一致）任务时左侧DLPFC激活增加（偏η = 0.432）。
补充白凤菜可能有能力改善DLPFC激活，在给药12周后可能会改善MCI老年人的工作记忆。
1 技术疗效：4期。
