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多酚补充对超重和肥胖成年人记忆功能的影响：系统评价和荟萃分析。

Effect of Polyphenol Supplementation on Memory Functioning in Overweight and Obese Adults: A Systematic Review and Meta-Analysis.

机构信息

Department of Psychology, Edge Hill University, Ormskirk L39 4QP, UK.

Department of Applied Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, UK.

出版信息

Nutrients. 2024 Feb 6;16(4):474. doi: 10.3390/nu16040474.

DOI:10.3390/nu16040474
PMID:38398799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10893550/
Abstract

Negative health consequences of obesity include impaired neuronal functioning and cell death, thus bringing the risk of impaired cognitive functioning. Antioxidant properties of polyphenols offer a possible intervention for overweight people, but evidence for their effectiveness in supporting cognitive functioning is mixed. This review examined evidence from randomized controlled trials concerning the effect of polyphenols on tasks requiring either immediate or delayed retrieval of learned information, respectively, thus controlling for differences in cognitive processes and related neural substrates supporting respective task demands. Searches of the PubMed/Medline, PsycInfo, and Scopus databases identified 24 relevant primary studies with N = 2336 participants having a BMI ≥ 25.0 kg/m. The participants' mean age for the 24 studies exceeded 60 years. Respective meta-analyses produced a significant summary effect for immediate retrieval but not for delayed retrieval. The present findings support a potential positive effect of chronic supplementation with polyphenols, most notably flavonoids, on immediate retrieval in participants aged over 60 years with obesity being a risk factor for cognitive impairment. We recommend further investigation of this potential positive effect in participants with such risk factors. Future research on all populations should report the phenolic content of the supplementation administered and be specific regarding the cognitive processes tested.

摘要

肥胖对健康的负面影响包括神经功能障碍和细胞死亡，从而增加认知功能障碍的风险。多酚的抗氧化特性为超重人群提供了一种可能的干预措施，但关于其在支持认知功能方面的有效性的证据存在分歧。本综述检查了来自随机对照试验的证据，这些试验分别涉及多酚对需要立即或延迟检索所学信息的任务的影响，从而控制了认知过程和支持各自任务需求的相关神经基质的差异。对 PubMed/Medline、PsycInfo 和 Scopus 数据库的搜索确定了 24 项相关的主要研究，涉及 N = 2336 名 BMI≥25.0 kg/m 的参与者。这 24 项研究的参与者平均年龄超过 60 岁。各自的荟萃分析显示，对于即时检索，存在显著的综合效应，但对于延迟检索则没有。本研究结果支持慢性补充多酚，尤其是类黄酮，对 60 岁以上肥胖人群即时检索的潜在积极影响，肥胖是认知障碍的一个风险因素。我们建议进一步研究这种潜在的积极影响在具有这些风险因素的参与者中。未来对所有人群的研究都应报告所给予的补充剂的酚类含量，并具体说明所测试的认知过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d47e/10893550/1277b6af169d/nutrients-16-00474-g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d47e/10893550/c30ddee72107/nutrients-16-00474-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d47e/10893550/e4420f6bca7b/nutrients-16-00474-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d47e/10893550/1201e8418b2f/nutrients-16-00474-g006.jpg
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